Table 2 Baseline reported history of colorectal and prostate cancer among first-degree, full-blood relatives and colorectal cancer risk in the WHI OS
Family History of cancer among 1st degree relatives | Colorectal cancer cases | Non-cases | p-value | Crude HR (95% CI) | Multivariable-adjusted HR (95% CI)a | ||
|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | ||||
Total (75,999) | 1122 | 1.5 | 74,877 | 98.5 | |||
Colorectal cancerb | <0.001 | ||||||
none | 907 | 80.8 | 63,678 | 85.0 | referent | referent | |
1 relative | 192 | 17.1 | 10,071 | 13.5 | 1.34 (1.14–1.56) | 1.34 (1.14–1.57) | |
> 1 relative | 23 | 2.0 | 1128 | 1.5 | 1.52 (1.00–2.29) | 1.40 (0.92–2.11) | |
Prostate cancer† | 0.999 | ||||||
none | 1015 | 90.5 | 67,737 | 90.5 | referent | referent | |
1 or more relative | 107 | 9.5 | 7140 | 9.5 | 0.97 (0.80–1.19) | 0.94(0.76–1.15) | |
Colorectal and Prostate cancer | <0.001 | ||||||
None | 834 | 74.3 | 58,053 | 77.5 | referent | referent | |
Colorectal only | 181 | 16.1 | 9684 | 12.9 | 1.30 (1.11–1.53) | 1.31 (1.11–1.54) | |
Prostate only | 73 | 6.5 | 5625 | 7.5 | 0.89 (0.70–1.13) | 0.88 (0.67–1.11) | |
Both | 34 | 3.0 | 1515 | 2.0 | 1.60 (1.14–2.26) | 1.48 (1.04–2.10) | |