Skip to main content

Table 5 Risk of interval versus screen-detected breast cancer for BMI and mammographic measures by tumor charactersitics

From: Mammographic density and risk of breast cancer by tumor characteristics: a case-control study

   

OPERA (95% CI)

  

Interval/ screen-detected cases

BMI + DA + NDA

BMI + PDA

BMI + DA

DA + NDA

PDA

DA

 

ER

       
 

BIC, AUC

 

492, 0.70

481, 0.70

492, 0.67

484, 0.69

474, 0.69

485, 0.66

BMI per 1 SD

 Positive

94/ 188

0.81 (0.63,1.05)

0.80 (0.62,1.04)

0.79 (0.60,1.02)

   
 

 Negative

45/ 45

0.77 (0.49,1.21)

0.79 (0.50,1.24)

0.79 (0.50,1.24)

   
   

P = 0.82

P = 0.95

P = 0.98

   

DA per adjusted 1SD

 Positive

 

1.55 (1.20,2.02)

 

1.58 (1.21,2.04)

1.54 (1.19,1.99)

 

1.55 (1.20,2.01)

 

 Negative

 

1.78 (1.12,2.82)

 

1.90 (1.20,3.00)

1.78 (1.12,2.84)

 

1.88 (1.19,2.97)

   

P = 0.61

 

P = 0.47

P = 0.58

 

P = 0.46

PDA per adjusted 1SD

 Positive

  

1.87 (1.41,2.48)

  

1.86 (1.41,2.47)

 
 

 Negative

  

2.22 (1.37,3.59)

  

2.21 (1.36,3.59)

 
    

P = 0.52

  

P = 0.53

 

NDA per adjusted 1SD

 Positive

 

0.68 (0.53,0.89)

  

0.67 (0.52,0.87)

  
 

 Negative

 

0.63 (0.40,0.98)

  

0.64 (0.41,1.00)

  
   

P = 0.75

  

P = 0.85

  
 

PR

       
 

BIC, AUC

 

488, 0.70

477, 0.70

488, 0.67

480, 0.69

470, 0.69

481, 0.66

BMI per 1 SD

 Positive

57/ 126

0.75 (0.55,1.03)

0.74 (0.54,1.02)

0.74 (0.53,1.02)

   
 

 Negative

80/ 106

0.84 (0.61,1.16)

0.85 (0.61,1.17)

0.82 (0.60,1.14)

   
   

P = 0.64

P = 0.56

P = 0.63

   

DA per adjusted 1SD

 Positive

 

1.65 (1.20,2.29)

 

1.67 (1.21,2.30)

1.59 (1.16,2.18)

 

1.60 (1.17,2.19)

 

 Negative

 

1.59 (1.15,2.20)

 

1.63 (1.18,2.25)

1.60 (1.16,2.22)

 

1.64 (1.19,2.27)

   

P = 0.86

 

P = 0.92

P = 0.97

 

P = 0.91

PDA per adjusted 1SD

 Positive

  

2.01 (1.42,2.85)

  

1.93 (1.38,2.71)

 
 

 Negative

  

1.91 (1.34,2.70)

  

1.94 (1.37,2.76)

 
    

P = 0.82

  

P = 0.98

 

NDA per adjusted 1SD

 Positive

 

0.64 (0.47,0.87)

  

0.64 (0.47,0.87)

  
 

 Negative

 

0.71 (0.51,0.99)

  

0.71 (0.51,0.98)

  
   

P = 0.61

  

P = 0.66

  
 

HER2

       
 

BIC, AUC

 

485, 0.70

478, 0.69

488, 0.66

475, 0.69

468, 0.68

479, 0.65

BMI per 1 SD

 Positive

41/ 73

0.93 (0.61,1.42)

0.92 (0.61,1.37)

0.88 (0.59,1.32)

   
 

 Negative

96/ 153

0.84 (0.64,1.10)

0.85 (0.65,1.12)

0.84 (0.64,1.10)

   
   

P = 0.70

P = 0.76

P = 0.84

   

DA per adjusted 1SD

 Positive

 

1.59 (1.06,2.40)

 

1.61 (1.08,2.40)

1.58 (1.06,2.35)

 

1.58 (1.07,2.34)

 

 Negative

 

1.51 (1.14,1.99)

 

1.58 (1.20,2.08)

1.51 (1.15,1.99)

 

1.58 (1.20,2.08)

   

P = 0.82

 

P = 0.95

P = 0.85

 

P = 1.00

PDA per adjusted 1SD

 Positive

  

1.75 (1.14,2.69)

  

1.75 (1.14,2.68)

 
 

 Negative

  

1.92 (1.43,2.57)

  

1.92 (1.43,2.58)

 
    

P = 0.72

  

P = 0.71

 

NDA per adjusted 1SD

 Positive

 

0.80 (0.50,1.30)

  

0.79 (0.49,1.25)

  
 

 Negative

 

0.58 (0.44,0.78)

  

0.58 (0.44,0.78)

  
   

P = 0.26

  

P = 0.29

  
 

Grade

       
 

BIC, AUC

 

497, 0.72

486, 0.70

495, 0.68

484, 0.71

473, 0.69

483, 0.67

BMI per 1 SD

 well differentiated

24/ 62

0.88 (0.55,1.42)

0.87 (0.55,1.38)

0.87 (0.54,1.38)

   
 

 moderately differentiated

52/ 104

0.67 (0.45,0.98)

0.68 (0.46,0.99)

0.65 (0.44,0.96)

   
 

 poorly differentiated

61/ 65

0.95 (0.66,1.35)

1.00 (0.71,1.40)

1.04 (0.75,1.44)

   
   

P = 0.39

P = 0.31

P = 0.19

   

DA per adjusted 1SD

 well differentiated

 

1.12 (0.69,1.84)

 

1.13 (0.69,1.83)

1.11 (0.68,1.81)

 

1.11 (0.69,1.80)

 

 moderately differentiated

 

1.97 (1.36,2.84)

 

1.99 (1.38,2.87)

1.92 (1.34,2.74)

 

1.93 (1.36,2.76)

 

 poorly differentiated

 

1.52 (1.05,2.19)

 

1.60 (1.12,2.28)

1.52 (1.05,2.20)

 

1.62 (1.14,2.30)

   

P = 0.18

 

P = 0.18

P = 0.19

 

P = 0.18

PDA per adjusted 1SD

 well differentiated

  

1.29 (0.79,2.11)

  

1.29 (0.79,2.11)

 
 

 moderately differentiated

  

2.16 (1.47,3.18)

  

2.13 (1.46,3.10)

 
 

 poorly differentiated

  

2.02 (1.37,2.99)

  

2.04 (1.38,3.01)

 
    

P = 0.23

  

P = 0.24

 

NDA per adjusted 1SD

 well differentiated

 

0.86 (0.55,1.33)

  

0.84 (0.54,1.30)

  
 

 moderately differentiated

 

0.82 (0.56,1.20)

  

0.81 (0.56,1.16)

  
 

 poorly differentiated

 

0.45 (0.30,0.70)

  

0.45 (0.29,0.70)

  
   

P = 0.06

  

P = 0.06

  
 

Size

       
 

BIC, AUC

 

513, 0.72

498, 0.72

509, 0.69

500, 0.71

485, 0.71

497, 0.68

BMI per 1 SD

 < 1 cm

25/ 76

0.74 (0.47,1.16)

0.74 (0.47,1.16)

0.71 (0.45,1.12)

   
 

 1–2 cm

51/ 116

0.71 (0.48,1.05)

0.70 (0.48,1.04)

0.68 (0.46,1.00)

   
 

 ≥ 2 cm

65/ 49

0.95 (0.64,1.40)

0.97 (0.66,1.42)

1.01 (0.71,1.46)

   
   

P = 0.54

P = 0.47

P = 0.27

   

DA per adjusted 1SD

 < 1 cm

 

1.49 (0.92,2.42)

 

1.55 (0.97,2.50)

1.52 (0.94,2.46)

 

1.58 (0.99,2.54)

 

 1–2 cm

 

1.26 (0.88,1.80)

 

1.27 (0.89,1.82)

1.29 (0.91,1.83)

 

1.31 (0.92,1.86)

 

 ≥ 2 cm

 

2.02 (1.39,2.94)

 

2.12 (1.46,3.07)

2.04 (1.41,2.95)

 

2.16 (1.50,3.10)

   

P = 0.16

 

P = 0.12

P = 0.18

 

P = 0.12

PDA per adjusted 1SD

 < 1 cm

  

1.75 (1.08,2.82)

  

1.81 (1.12,2.93)

 
 

 1–2 cm

  

1.48 (1.01,2.15)

  

1.54 (1.07,2.22)

 
 

 ≥ 2 cm

  

2.67 (1.77,4.03)

  

2.70 (1.80,4.06)

 
    

P = 0.07

  

P = 0.09

 

NDA per adjusted 1SD

 < 1 cm

 

0.75 (0.50,1.13)

  

0.73 (0.49,1.10)

  
 

 1–2 cm

 

0.74 (0.53,1.02)

  

0.72 (0.52,0.99)

  
 

 ≥ 2 cm

 

0.49 (0.30,0.81)

  

0.49 (0.30,0.81)

  
   

P = 0.33

  

P = 0.37

  
 

Nodal Status

       
 

BIC, AUC

 

481, 0.72

475, 0.71

487, 0.68

475, 0.71

469, 0.69

480, 0.66

BMI per 1 SD

 Positive

65/ 39

0.58 (0.38,0.90)

0.61 (0.41,0.93)

0.64 (0.42,0.97)

   
 

 Negative

71/ 190

1.04 (0.81,1.35)

1.04 (0.81,1.35)

1.02 (0.79,1.32)

   
   

P = 0.02

P = 0.03

P = 0.06

   

DA per adjusted 1SD

 Positive

 

1.75 (1.18,2.58)

 

1.97 (1.33,2.91)

1.60 (1.09,2.36)

 

1.77 (1.22,2.55)

 

 Negative

 

1.48 (1.12,1.95)

 

1.49 (1.13,1.96)

1.47 (1.12,1.94)

 

1.48 (1.13,1.95)

   

P = 0.48

 

P = 0.23

P = 0.71

 

P = 0.43

PDA per adjusted 1SD

 Positive

  

2.47 (1.63,3.74)

  

2.19 (1.46,3.28)

 
 

 Negative

  

1.71 (1.28,2.30)

  

1.70 (1.27,2.28)

 
    

P = 0.13

  

P = 0.29

 

NDA per adjusted 1SD

 Positive

 

0.44 (0.27,0.70)

  

0.45 (0.28,0.74)

  
 

 Negative

 

0.73 (0.56,0.95)

  

0.74 (0.57,0.96)

  
   

P = 0.05

  

P = 0.07

  
  1. Abbreviations: AUC area under the receiver operating characteristic curve, BIC Bayesian information criterion, BMI body mass index, CI confidence interval, DA dense area, NDA non-dense area, OPERA Odds per Adjusted Standard Deviation, PDA percent dense area, SD standard deviation
  2. All of the estimates from conditional logistic regression are adjusted for age at mammogram
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us