From: Mammographic density and risk of breast cancer by tumor characteristics: a case-control study
OPERA (95% CI) | ||||||||
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Cases/ controls | BMI + DA + NDA | BMI + PDA | BMI + DA | DA + NDA | PDA | DA | ||
ER | ||||||||
BIC, AUC | 1130, 0.67 | 1117, 0.67 | 1130, 0.66 | 1108, 0.67 | 1094, 0.66 | 1107, 0.65 | ||
BMI per 1 SD at age 50 | Positive | 314/ 916 | 0.82 (0.61,1.11) | 0.83 (0.61,1.12) | 0.82 (0.60,1.11) | |||
Negative | 106/ 316 | 0.93 (0.62,1.41) | 0.91 (0.60,1.36) | 0.89 (0.59,1.35) | ||||
BMI per 1 SD at age 70 | Positive | 1.23 (1.04,1.46) | 1.23 (1.04,1.45) | 1.23 (1.04,1.45) | ||||
Negative | 1.12 (0.79,1.60) | 1.12 (0.79,1.60) | 1.11 (0.78,1.58) | |||||
P for interaction with age = 0.07 | P for interaction with age = 0.08 | P for interaction with age = 0.06 | ||||||
P = 0.83 | P = 0.88 | P = 0.86 | ||||||
DA per adjusted 1SD | Positive | 1.32 (1.16,1.51) | 1.34 (1.18,1.53) | 1.33 (1.17,1.52) | 1.35 (1.19,1.54) | |||
Negative | 1.50 (1.18,1.90) | 1.54 (1.21,1.95) | 1.49 (1.18,1.89) | 1.52 (1.21,1.92) | ||||
P = 0.36 | P = 0.33 | P = 0.41 | P = 0.38 | |||||
PDA per adjusted 1SD | Positive | 1.42 (1.24,1.63) | 1.43 (1.25,1.64) | |||||
Negative | 1.72 (1.33,2.23) | 1.71 (1.32,2.20) | ||||||
P = 0.20 | P = 0.23 | |||||||
NDA per adjusted 1SD | Positive | 0.86 (0.76,0.98) | 0.86 (0.76,0.98) | |||||
Negative | 0.69 (0.54,0.88) | 0.69 (0.54,0.88) | ||||||
P = 0.10 | P = 0.10 | |||||||
PR | ||||||||
BIC, AUC | 1115, 0.68 | 1101, 0.68 | 1113, 0.67 | 1099, 0.67 | 1085, 0.66 | 1097, 0.65 | ||
BMI per 1 SD at age 50 | Positive | 206/ 604 | 0.77 (0.54,1.10) | 0.78 (0.55,1.11) | 0.77 (0.54,1.10) | |||
Negative | 210/ 615 | 0.98 (0.70,1.36) | 0.96 (0.69,1.33) | 0.93 (0.67,1.30) | ||||
BMI per 1 SD at age 70 | Positive | 1.46 (1.18,1.81) | 1.46 (1.18,1.80) | 1.46 (1.18,1.80) | ||||
Negative | 0.95 (0.76,1.19) | 0.94 (0.75,1.18) | 0.95 (0.75,1.18) | |||||
P for interaction with age = 0.01 | P for interaction with age = 0.02 | P for interaction with age = 0.02 | ||||||
P = 0.02 | P = 0.02 | P = 0.02 | ||||||
DA per adjusted 1SD | Positive | 1.35 (1.15,1.59) | 1.36 (1.16,1.60) | 1.35 (1.15,1.59) | 1.36 (1.16,1.60) | |||
Negative | 1.36 (1.16,1.60) | 1.43 (1.21,1.68) | 1.36 (1.16,1.60) | 1.42 (1.21,1.67) | ||||
P = 0.96 | P = 0.69 | P = 0.97 | P = 0.71 | |||||
PDA per adjusted 1SD | Positive | 1.45 (1.22,1.72) | 1.45 (1.22,1.72) | |||||
Negative | 1.54 (1.30,1.82) | 1.53 (1.29,1.82) | ||||||
P = 0.64 | P = 0.64 | |||||||
NDA per adjusted 1SD | Positive | 0.87 (0.75,1.02) | 0.88 (0.75,1.02) | |||||
Negative | 0.76 (0.64,0.90) | 0.76 (0.64,0.90) | ||||||
P = 0.24 | P = 0.23 | |||||||
HER2 | ||||||||
BIC, AUC | 1105, 0.68 | 1093, 0.67 | 1103, 0.66 | 1083, 0.67 | 1071, 0.66 | 1081, 0.65 | ||
BMI per 1 SD at age 50 | Positive | 129/ 381 | 0.76 (0.49,1.17) | 0.78 (0.51,1.18) | 0.75 (0.49,1.16) | |||
Negative | 281/ 824 | 0.92 (0.68,1.25) | 0.92 (0.68,1.25) | 0.90 (0.66,1.23) | ||||
BMI per 1 SD at age 70 | Positive | 1.06 (0.81,1.40) | 1.06 (0.81,1.40) | 1.06 (0.81,1.40) | ||||
Negative | 1.26 (1.05,1.53) | 1.25 (1.04,1.51) | 1.25 (1.03,1.50) | |||||
P for interaction with age = 0.12 | P for interaction with age = 0.14 | P for interaction with age = 0.11 | ||||||
P = 0.41 | P = 0.47 | P = 0.46 | ||||||
DA per adjusted 1SD | Positive | 1.52 (1.24,1.87) | 1.53 (1.24,1.89) | 1.51 (1.23,1.85) | 1.52 (1.24,1.87) | |||
Negative | 1.31 (1.14,1.51) | 1.36 (1.18,1.56) | 1.32 (1.15,1.51) | 1.36 (1.18,1.56) | ||||
P = 0.25 | P = 0.34 | P = 0.28 | P = 0.38 | |||||
PDA per adjusted 1SD | Positive | 1.56 (1.25,1.94) | 1.55 (1.25,1.93) | |||||
Negative | 1.47 (1.27,1.70) | 1.47 (1.27,1.70) | ||||||
P = 0.67 | P = 0.69 | |||||||
NDA per adjusted 1SD | Positive | 0.97 (0.78,1.19) | 0.96 (0.78,1.18) | |||||
Negative | 0.77 (0.66,0.89) | 0.77 (0.67,0.89) | ||||||
P = 0.08 | P = 0.08 | |||||||
Grade | ||||||||
BIC, AUC | 1146, 0.67 | 1125, 0.67 | 1137, 0.66 | 1111, 0.66 | 1090, 0.66 | 1103, 0.65 | ||
BMI per 1 SD at age 50 | well differentiated | 96/ 271 | 0.93 (0.60,1.45) | 0.94 (0.61,1.47) | 0.94 (0.60,1.47) | |||
moderately differentiated | 172/ 511 | 0.65 (0.40,1.05) | 0.66 (0.41,1.06) | 0.64 (0.39,1.03) | ||||
poorly differentiated | 146/ 436 | 0.94 (0.66,1.35) | 0.94 (0.66,1.33) | 0.93 (0.65,1.33) | ||||
BMI per 1 SD at age 70 | well differentiated | 0.93 (0.60,1.45) | 1.02 (0.70,1.49) | 1.01 (0.69,1.48) | ||||
moderately differentiated | 0.65 (0.40,1.05) | 1.29 (1.03,1.63) | 1.30 (1.04,1.64) | |||||
poorly differentiated | 0.94 (0.66,1.35) | 1.22 (0.96,1.54) | 1.23 (0.98,1.56) | |||||
P for interaction with age = 0.07 | P for interaction with age = 0.07 | P for interaction with age = 0.05 | ||||||
P = 0.65 | P = 0.66 | P = 0.58 | ||||||
DA per adjusted 1SD | well differentiated | 1.31 (1.03,1.67) | 1.35 (1.06,1.72) | 1.31 (1.03,1.67) | 1.35 (1.06,1.72) | |||
moderately differentiated | 1.39 (1.16,1.67) | 1.42 (1.19,1.71) | 1.39 (1.17,1.66) | 1.43 (1.19,1.71) | ||||
poorly differentiated | 1.35 (1.12,1.64) | 1.36 (1.12,1.64) | 1.35 (1.11,1.64) | 1.36 (1.12,1.64) | ||||
P = 0.93 | P = 0.92 | P = 0.93 | P = 0.91 | |||||
PDA per adjusted 1SD | well differentiated | 1.51 (1.17,1.95) | 1.51 (1.17,1.95) | |||||
moderately differentiated | 1.49 (1.23,1.80) | 1.50 (1.25,1.81) | ||||||
poorly differentiated | 1.46 (1.19,1.79) | 1.47 (1.20,1.80) | ||||||
P = 0.98 | P = 0.98 | |||||||
NDA per adjusted 1SD | well differentiated | 0.81 (0.63,1.04) | 0.81 (0.63,1.04) | |||||
moderately differentiated | 0.87 (0.72,1.05) | 0.86 (0.71,1.04) | ||||||
poorly differentiated | 0.76 (0.63,0.91) | 0.75 (0.62,0.90) | ||||||
P = 0.61 | P = 0.60 | |||||||
Size | ||||||||
BIC, AUC | 1166, 0.69 | 1145, 0.69 | 1160, 0.68 | 1130, 0.68 | 1110, 0.68 | 1125, 0.67 | ||
BMI per 1 SD at age 50 | < 1 cm | 106/ 296 | 0.78 (0.51,1.20) | 0.78 (0.51,1.21) | 0.78 (0.51,1.20) | |||
1–2 cm | 186/ 552 | 0.77 (0.51,1.16) | 0.78 (0.52,1.18) | 0.76 (0.51,1.15) | ||||
≥ 2 cm | 137/ 411 | 0.95 (0.61,1.49) | 0.93 (0.60,1.45) | 0.89 (0.57,1.41) | ||||
BMI per 1 SD at age 70 | < 1 cm | 1.46 (1.03,2.07) | 1.45 (1.02,2.06) | 1.45 (1.02,2.05) | ||||
1–2 cm | 1.15 (0.93,1.43) | 1.15 (0.93,1.42) | 1.15 (0.93,1.42) | |||||
≥ 2 cm | 1.14 (0.86,1.52) | 1.17 (0.88,1.55) | 1.19 (0.90,1.57) | |||||
P for interaction with age = 0.06 | P for interaction with age = 0.06 | P for interaction with age = 0.05 | ||||||
P = 0.74 | P = 0.79 | P = 0.81 | ||||||
DA per adjusted 1SD | < 1 cm | 1.00 (0.80,1.25) | 1.00 (0.80,1.26) | 1.00 (0.80,1.25) | 1.00 (0.80,1.26) | |||
1–2 cm | 1.32 (1.12,1.57) | 1.36 (1.14,1.61) | 1.32 (1.11,1.56) | 1.35 (1.14,1.60) | ||||
≥ 2 cm | 1.81 (1.45,2.25) | 1.83 (1.47,2.27) | 1.82 (1.46,2.26) | 1.84 (1.48,2.29) | ||||
P < 0.01 | P < 0.01 | P < 0.01 | P < 0.01 | |||||
PDA per adjusted 1SD | < 1 cm | 1.04 (0.83,1.31) | 1.04 (0.83,1.30) | |||||
1–2 cm | 1.48 (1.24,1.77) | 1.48 (1.24,1.77) | ||||||
≥ 2 cm | 2.06 (1.61,2.63) | 2.08 (1.63,2.65) | ||||||
P < 0.01 | P < 0.01 | |||||||
NDA per adjusted 1SD | < 1 cm | 0.93 (0.75,1.16) | 0.95 (0.76,1.17) | |||||
1–2 cm | 0.80 (0.67,0.95) | 0.80 (0.67,0.95) | ||||||
≥ 2 cm | 0.71 (0.57,0.88) | 0.70 (0.56,0.87) | ||||||
P = 0.20 | P = 0.14 | |||||||
Nodal status | ||||||||
BIC, AUC | 1074, 0.69 | 1062, 0.69 | 1075, 0.68 | 1052, 0.68 | 1041, 0.68 | 1054, 0.67 | ||
BMI per 1 SD at age 50 | Positive | 116/ 341 | 1.09 (0.68,1.75) | 1.09 (0.68,1.73) | 1.02 (0.63,1.63) | |||
Negative | 288/ 844 | 0.78 (0.58,1.04) | 0.78 (0.58,1.05) | 0.78 (0.58,1.04) | ||||
BMI per 1 SD at age 70 | Positive | 1.12 (0.81,1.53) | 1.11 (0.82,1.51) | 1.10 (0.81,1.49) | ||||
Negative | 1.24 (1.04,1.49) | 1.24 (1.04,1.48) | 1.25 (1.04,1.49) | |||||
P for interaction with age = 0.04 | P for interaction with age = 0.04 | P for interaction with age = 0.03 | ||||||
P = 0.46 | P = 0.47 | P = 0.56 | ||||||
DA per adjusted 1SD | Positive | 1.90 (1.49,2.43) | 1.89 (1.49,2.41) | 1.92 (1.51,2.46) | 1.91 (1.51,2.43) | |||
Negative | 1.24 (1.08,1.42) | 1.27 (1.11,1.45) | 1.24 (1.09,1.42) | 1.27 (1.11,1.45) | ||||
P < 0.01 | P < 0.01 | P < 0.01 | P < 0.01 | |||||
PDA per adjusted 1SD | Positive | 2.11 (1.62,2.75) | 2.13 (1.64,2.78) | |||||
Negative | 1.34 (1.16,1.54) | 1.34 (1.17,1.55) | ||||||
P < 0.01 | P < 0.01 | |||||||
NDA per adjusted 1SD | Positive | 0.67 (0.53,0.85) | 0.68 (0.54,0.85) | |||||
Negative | 0.86 (0.75,0.99) | 0.86 (0.75,0.98) | ||||||
P = 0.07 | P = 0.09 |