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Fig. 6 | BMC Cancer

Fig. 6

From: High mobility group box 1 promotes sorafenib resistance in HepG2 cells and in vivo

Fig. 6

Potential mechanism of HMGB1-induced sorafenib resistance in HCC. Sorafenib targets Raf-1, B-Raf, and eIF4E phosphorylation, which leads to the inhibition of proliferation and induces apoptosis. However, intracellular HMGB1 promotes the downstream MAPK cascade through Erk1/2 phosphorylation. Then, phospho-Erk attenuates the competition between phospho-Bcl-2 and HMGB1 binding to Beclin 1. Nuclear HMGB1 and HSP27 maintain mitophagy and act as co-factors to block apoptosis. Meanwhile, through the HMGB1/RAGE axis, extracellular HMGB1 indirectly promotes tumour growth by accelerating ATP production

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