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Fig. 5 | BMC Cancer

Fig. 5

From: High mobility group box 1 promotes sorafenib resistance in HepG2 cells and in vivo

Fig. 5

Suppression of HMGB1 increases the sensitivity to sorafenib in vivo (*p < 0.05; **p < 0.01). HepG2 cells stably expressing sh-HMGB1 or sh-control were injected subcutaneously into the flanks of nude mice administered sorafenib (40 mg/kg/day for 21 days). a Tumour growth curves in the different groups were recorded. b Images of dissected tumours from each group (n = 5) at the end of the experiment. c HE staining of the tumours. d Immunohistochemical analysis and quantitative evaluation of xenograft tumour tissues using HMGB1 antibodies

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