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Fig. 2 | BMC Cancer

Fig. 2

From: Transcriptome analysis of genes associated with breast cancer cell motility in response to Artemisinin treatment

Fig. 2

Artemisinin exhibits anti-migratory, anti-invasion and apoptosis inducing property in breast cancer cells. A (I) Picture represent relative cell migration in both control and treated MCF-7 cells at different time intervals. (II) Graph represents the quantification of the decrease in the area as wound healing progresses at the observed time points. Significant differences were observed between control and treated cells at different time points p (<0.0001). B (I) Image depicts the cell migration in control and artemisinin treated MCF7 cells as observed in transwell migration assay. (II) Graph depicts the average number of migrated cells. C (I) Diagram represents relative invasion in control and artemisinin treated aggressive breast cancer cells. (II) Relative invasion in depicted in the graph. D (I) Dot plot representing PE Annexin V positive, 7AAD negative MCF-7 cells after 24 h of treatment with 1 μM artemisinin, control (DMSO < 0.01%)μ and plumbagin (5 μM) as positive control. The lower left quadrants of each panels show the viable cells and 7-AAD negative, lower right quadrants represent the early apoptotic cells (PE Annexin V positive and 7-AAD negative). (II) Graph represents the percentage of early apoptotic cells in control and artemisinin treated MCF-7 cells computed from three biologically different set of experiments. Significant differences were observed between control and treated cells, *p < 0.05

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