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Table 3 Associations between the clinical and laboratory characteristics of the patients and location of CRC in univariate and multivariate logistic regression analysis in the validation cohort

From: Clinical baseline and prognostic difference of platelet lymphocyte ratio (PLR) in right-sided and let-sided colon cancers

Characteristic

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Age (< 59 years vs. ≥ 59)

1.481

1.135–1.933

0.004

1.384

1.036–1.848

0.028

Gender (Male vs. Female)

1.098

0.841–1.435

0.491

   

CRP, mg/L (≥ 3.26 vs. < 3.26)

2.126

1.625–2.781

<0.001

   

WBCs, ×109 (≥ 6.4 vs. < 6.4)

1.061

0.815–1.382

0.660

   

Neutrophils, ×109 (≥ 3.9 vs. < 3.9)

1.441

1.105–1.878

0.007

   

Platelets, ×109 (≥ 252 vs. < 252)

1.545

1.125–2.121

0.007

   

ALB, g/L (≥ 40.5 vs. < 40.5)

0.488

0.373–0.638

<0.001

0.532

0.398–0.710

<0.001

CA199, U/mL (≥ 27 vs. < 27)

1.221

0.899–1.657

0.200

   

CEA, ng/mL (≥ 5 vs. < 5)

1.174

0.894–1.541

0.248

   

T lymphocytes, ×109 (≥1.6vs. < 1.6)

0.772

0.592–1.006

0.055

   

Monocytes, ×109 (≥ 0.4 vs. < 0.4)

1.046

0.803–1.362

0.741

   

MMR, (P vs. D)

0.259

0.163–0.411

<0.001

0.317

0.195–0.515

<0.001

TNM

  

<0.001

  

0.011

 1

1.000

1.000

 

1.000

1.000

 

 2

2.991

1.753–5.103

<0.001

2.365

1.357–4.123

0.002

 3

2.505

1.432–4.384

0.001

2.175

1.215–3.892

0.009

 4

3.462

1.803–6.648

<0.001

2.963

1.501–5.850

0.002

PLR

2.233

1.703–2.927

<0.001

1.451

1.056–1.993

0.022

NLR

1.507

1.155–1.965

0.002

   

CAR

2.232

1.705–2.923

<0.001

   

PNI

1.040

0.798–1.355

0.771

   

mGPS

  

<0.001

   

 0

1.000

1.000

    

 1

3.099

1.989–4.828

<0.001

   

 2

1.695

1.022–2.812

0.041

   
  1. Abbreviations: CRP C-reactive protein, WBCs White blood cells, ALB Albumin, CA199 Carbohydrate Atigen 19–9, CEA Carcinoembryonic antigen, MMR Mismatch repair, PLR The platelet to lymphocyte ratio, NLR The neutrophil to lymphocyte ratio; PNI, 10 × serum albumin value (g/dl) + 0.005 × peripheral lymphocyte count (per mm3), mGPS Glasgow Prognostic Score incorporates raised circulating C-reactive protein (CRP) and hypoalbuminemia; Undifferentiated, undifferentiated non-keratinizing carcinoma; Differentiated, differentiated carcinoma
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BMC Cancer

ISSN: 1471-2407

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