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Table 2 Associations between the clinical and laboratory characteristics of the patients and location of CRC in univariate and multivariate logistic regression analysis in the training cohort

From: Clinical baseline and prognostic difference of platelet lymphocyte ratio (PLR) in right-sided and let-sided colon cancers

Characteristic

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Age (< 59 years vs. ≥ 59)

1.275

0.980–1.660

0.071

   

Gender (Male vs. Female)

1.212

0.926–1.586

0.162

   

CRP, mg/L (≥ 3.26 vs. < 3.26)

1.393

1.069–1.813

0.014

  

0.835

WBCs, ×109 (≥ 6.4 vs. < 6.4)

1.194

0.918–1.552

0.186

   

Neutrophils, ×109 (≥ 3.9 vs. < 3.9)

1.084

0.834–1.410

0.546

   

Platelets, ×109 (≥ 252 vs. < 252)

2.013

1.543–2.626

<0.001

1.563

1.151–2.124

0.004

ALB, g/L (≥ 40.5 vs. < 40.5)

0.709

0.545–0.922

0.010

  

0.275

CA199, U/mL (≥ 27 vs. < 27)

1.091

0.817–1.458

0.555

  

0.635

CEA, ng/mL (≥ 5 vs. < 5)

1.504

1.154–1.959

0.003

1.819

1.350–2.450

<0.001

T lymphocytes, ×109 (≥1.6vs. < 1.6)

0.894

0.688–1.163

0.404

   

Monocytes, ×109 (≥ 0.4 vs. < 0.4)

0.987

0.759–1.284

0.923

   

MMR, (P vs. D)

0.303

0.207–0.441

<0.001

0.309

0.209–0.457

<0.001

Chemotherapy

 No

1.220

0.911–1.634

0.182

   

 Yes

1.252

0.932–1.681

0.135

   

 0.237 Unknown

1.026

0.767–1.372

0.862

   

Radiotherapy

 No

1.234

0.920–1.655

0.160

   

 Yes

1.235

0.871–1.750

0.237

   

 Unknown

0.975

0.678–1.401

0.889

   

TNM

  

<0.001

  

0.001

 1

1.000

1.000

 

1.000

1.000

 

 2

3.483

1.903–6.375

<0.001

3.126

1.665–5.869

<0.001

 3

2.517

1.351–4.689

0.004

2.470

1.291–4.725

0.006

 4

2.452

1.310–4.590

0.005

2.345

1.217–4.516

0.011

PLR

1.834

1.407–2.391

<0.001

1.454

1.071–1.975

1.4540.022d

NLR

1.411

1.084–1.836

0.010

  

0.443

CAR

1.482

1.137–1.930

0.004

  

0.428

PNI

1.111

0.855–1.444

0.431

   

mGPS

  

0.004

  

0.428

 0

1.000

1.000

    

 1

1.678

1.233–2.285

0.001

  

0.195

 2

1.313

0.859–2.008

0.208

  

0.850

  1. Abbreviations: CRP C-reactive protein, WBCs White blood cells, ALB Albumin, CA199 Carbohydrate Atigen 19–9, CEA Carcinoembryonic antigen, MMR Mismatch repair, PLR The platelet to lymphocyte ratio, NLR The neutrophil to lymphocyte ratio; PNI, 10 × serum albumin value (g/dl) + 0.005 × peripheral lymphocyte count (per mm3), mGPS Glasgow Prognostic Score incorporates raised circulating C-reactive protein (CRP) and hypoalbuminemia; Undifferentiated, undifferentiated non-keratinizing carcinoma; Differentiated, differentiated carcinoma