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Table 3 Weight values and categorization of tissue types

From: Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues

Consequence

Damage immediately life

Damage life threatening

Damage not immediately

 

threatening

 

life threatening

Weight

1

0.8

0.5

Tissues

Lung/Respiratory system

Digestive system

Urinary bladder

 

Brain/Nervous system

(except appendix)

Various glands

 

Blood/Immune system

Soft tissue

Prostate

 

Heart

 

Skin

 

Kidney

 

Eye a

 

Liver

  

Consequence

Damage not life

Tissue not affected

 
 

threatening

  

Weight

0.3

0

 

Tissues

Reproductive organs

Cancer cell lines

 
 

Mammary tissue

Testis

 
 

Tonsils

Fetal tissue

 
 

Appendix

  
 

Gall bladder

  
 

Spleen

  
  1. aThe weight for eye tissue is set to 0.5, as T cells are able to infiltrate it [30]
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BMC Cancer

ISSN: 1471-2407

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