Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

BMC Cancer

Table 4 Association between clinicopathological parameters and Akt, p-Akt, mTOR, p-mTOR expression in 120 cases of gastric cancer

		Total patients	AKT-positive	AKT-negative	P value	p-AKT-positive	p-AKT-negative	P value	mTOR-positive	mTOR-negative	P value	p-mTOR-positive	p-mTOR-negative	P value
Sex	Male	80	55	25	0.49	46	34	0.60	50	30	0.60	46	34	0.30
Sex	Female	40	25	15		25	15		23	17		19	21
Age	<60y	49	25	24	<0.01	28	21	0.71	21	28	<0.01	26	23	0.84
Age	>60y	71	55	16		43	28		52	19		39	32
Tumor size	<3 cm	15	11	4	1.00	9	6	0.94	9	6	0.58	9	6	0.63
Tumor size	>3 cm	105	69	36		62	43		64	41		56	49
Differentiation	Well/moderate	102	69	33	0.59	59	43	0.48	60	42	0.28	49	53	<0.01
Differentiation	Poor	18	11	7		12	6		13	5		16	2
Tumor location	Upper/Medium	77	46	31	0.03	46	31	0.86	49	28	0.40	43	34	0.62
Tumor location	Low	43	34	9		25	18		24	19		22	21
Depth of invasion	T1 + T2	22	14	8	0.74	9	13	0.054	10	12	0.10	6	16	<0.01
Depth of invasion	T3 + T4	98	66	32		62	36		63	35		59	39
LN metastasis	N0	25	18	7	0.53	12	13	0.20	12	13	0.14	9	16	0.04
LN metastasis	N1 + N2 + N3	95	62	33		59	36		61	34		56	39
Metastasis	M0	114	77	37	0.66	70	44	0.08	70	44	0.58	63	51	0.53
Metastasis	M1	6	3	3		1	5		3	3		2	4
TNM stage	I + II	33	21	12	0.67	20	13	0.84	15	18	0.03	12	21	0.02
TNM stage	III + IV	87	59	28		51	36		58	29		53	34

ISSN: 1471-2407