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Table 4 Association between clinicopathological parameters and Akt, p-Akt, mTOR, p-mTOR expression in 120 cases of gastric cancer

From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

   Total patients AKT-positive AKT-negative P value p-AKT-positive p-AKT-negative P value mTOR-positive mTOR-negative P value p-mTOR-positive p-mTOR-negative P value
Sex Male 80 55 25 0.49 46 34 0.60 50 30 0.60 46 34 0.30
Female 40 25 15   25 15   23 17   19 21  
Age <60y 49 25 24 <0.01 28 21 0.71 21 28 <0.01 26 23 0.84
>60y 71 55 16   43 28   52 19   39 32  
Tumor size <3 cm 15 11 4 1.00 9 6 0.94 9 6 0.58 9 6 0.63
>3 cm 105 69 36   62 43   64 41   56 49  
Differentiation Well/moderate 102 69 33 0.59 59 43 0.48 60 42 0.28 49 53 <0.01
Poor 18 11 7   12 6   13 5   16 2  
Tumor location Upper/Medium 77 46 31 0.03 46 31 0.86 49 28 0.40 43 34 0.62
Low 43 34 9   25 18   24 19   22 21  
Depth of invasion T1 + T2 22 14 8 0.74 9 13 0.054 10 12 0.10 6 16 <0.01
T3 + T4 98 66 32   62 36   63 35   59 39  
LN metastasis N0 25 18 7 0.53 12 13 0.20 12 13 0.14 9 16 0.04
N1 + N2 + N3 95 62 33   59 36   61 34   56 39  
Metastasis M0 114 77 37 0.66 70 44 0.08 70 44 0.58 63 51 0.53
M1 6 3 3   1 5   3 3   2 4  
TNM stage I + II 33 21 12 0.67 20 13 0.84 15 18 0.03 12 21 0.02
III + IV 87 59 28   51 36   58 29   53 34