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Table 2 Association between clinicopathological parameters, proteins and HER2, HER3, HER2-HER3 co-expression in 120 cases of gastric cancer

From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

 

Total patients

HER2-positive

HER2-negative

P value

HER3-positive

HER3-negative

P value

HER2/HER3 co-expression

P value

Sex

Male

80

19

61

0.88

42

38

0.60

16

0.75

Female

40

10

30

 

23

17

 

9

 

Age

<60y

49

9

40

0.02

24

25

0.34

7

0.14

>60y

71

20

51

 

41

30

 

18

 

Tumor size

<3 cm

15

4

11

1.00

7

8

0.53

4

0.80

>3 cm

105

25

80

 

58

47

 

21

 

Differentiation

Well/moderate

102

20

82

0.01

52

50

0.10

17

0.02

Poor

18

9

9

 

13

5

 

8

 

Tumor location

Upper/Medium

77

17

60

0.47

42

35

0.91

16

0.98

Low

43

12

31

 

23

20

 

9

 

Depth of invasion

T1 + T2

22

4

18

0.47

7

15

0.02

2

0.23

T3 + T4

98

25

73

 

58

40

 

23

 

Lymph node metastasis

N0

25

6

19

0.98

11

14

0.25

6

0.59

N1 + N2 + N3

95

23

72

 

54

41

 

19

 

Metastasis

M0

114

25

89

0.045

62

52

1.00

23

0.80

M1

6

4

2

 

3

3

 

2

 

TNM stage

I + II

33

5

28

0.16

17

16

0.72

5

0.35

III + IV

87

24

63

 

48

39

 

20

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