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Table 2 Association between clinicopathological parameters, proteins and HER2, HER3, HER2-HER3 co-expression in 120 cases of gastric cancer

From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

  Total patients HER2-positive HER2-negative P value HER3-positive HER3-negative P value HER2/HER3 co-expression P value
Sex Male 80 19 61 0.88 42 38 0.60 16 0.75
Female 40 10 30   23 17   9  
Age <60y 49 9 40 0.02 24 25 0.34 7 0.14
>60y 71 20 51   41 30   18  
Tumor size <3 cm 15 4 11 1.00 7 8 0.53 4 0.80
>3 cm 105 25 80   58 47   21  
Differentiation Well/moderate 102 20 82 0.01 52 50 0.10 17 0.02
Poor 18 9 9   13 5   8  
Tumor location Upper/Medium 77 17 60 0.47 42 35 0.91 16 0.98
Low 43 12 31   23 20   9  
Depth of invasion T1 + T2 22 4 18 0.47 7 15 0.02 2 0.23
T3 + T4 98 25 73   58 40   23  
Lymph node metastasis N0 25 6 19 0.98 11 14 0.25 6 0.59
N1 + N2 + N3 95 23 72   54 41   19  
Metastasis M0 114 25 89 0.045 62 52 1.00 23 0.80
M1 6 4 2   3 3   2  
TNM stage I + II 33 5 28 0.16 17 16 0.72 5 0.35
III + IV 87 24 63   48 39   20