Fig. 10From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patientsThe function mechanism of HER2-HER3 co-expression. HER2-HER3 heterodimer is the effective dimer that can enhance the phosphorylation of Akt and mTOR, promotes translation, angiogenesis, EMT, cell proliferation. However, HER2 or HER3 hemodimier has no function that could not activiate PI3K/Akt/mTOR pathway, because of different deficiencies of themselvesBack to article page