Pathologic analysis of non-neoplastic parenchyma in renal cell carcinoma: a comprehensive observation in radical nephrectomy specimens

Table 3 Histologic assessment of non-neoplastic parenchyma in four groups divided according to the distance from the PC or tumor margin

	GROUP 1 (0-2 mm) ***		GROUP 2 (2-5 mm)		GROUP 3 (5-10 mm)		GROUP 4 (10-20 mm)
	No. (%)*	Grade**	No. (%)	Grade	No. (%)	Grade	No. (%)	Grade	P value
CI	53(100)	2.1 (0.6)	29(54.7)	0.72(0.7)	14 (26.4)	0.2(0.2)	8 (15.1)	0.1 (0.13)	<0.001
GS	28(52.8)	0.7 (0.9)	11(20.8)	0.1(0.3)	7 (13.2)	0.09(0.2)	4 (7.5)	0.1(0.1)	<0.001
AS	23(43.4)	0.5 (0.8)	8(15.1)	0.1 (0.3)	5 (9.4)	0.1(0.1)	3 (5.7)	0.1 (0.7)	<0.001
NS	52(98.1)	1.90(0.8)	30(56.6)	0.4 (0.4)	3 (5.7)	0.1(1.0)	2 (3.8)	0.1(0.2)	<0.001

For all 53 specimens, we grouped the 20 subsections (1 mm wide) into four intervals of variable widths according to their distance from the PC or tumor edge. Finding the histological change in any subsection of the group was defined as positive occurrence. The frequency of each change among the four groups was recorded. The grade score of each histologic change was calculated by averaging all subsection scores in the four groups to represent the overall severity of lesion
*Number and precentage of specimens that presents the corresponding histologic change;
**Average grade score and standard deviation of all 53 specimens;
***The distant from pseudo-capsule or tumor margin

ISSN: 1471-2407