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Table 5 Comparison of Diagnostic Performance of MMP-9 and its Combination with MMP-1 and/or MMP-7 for Non-Small Cell Lung Cancer Detection

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Modela AUC Sensitivity %
(95% CI)b
Specificity %
(95% CI) b
Youden Index
MMP-9 + Gn + Ag + Smk 0.787 (0.720–0.845) 85.54
(76.1–92.3)
64.89
(54.4–74.5)
>0.419
MMP-9 + MMP-1 + Gn + Ag + Smk 0.787 (0.720–0.845) 85.54
(76.1–92.3)
64.89
(54.4–74.5)
>0.421
MMP-9 + MMP-7 + Gn + Ag + Smk 0.786 (0.718–0.844) 81.93
(72–89.5)
64.52
(53.9–74.2)
>0.413
MMP-9 + MMP-1 + MMP-7 + Gn + Ag + Smk 0.788 (0.720–0.845) 81.93
(72–89.5)
64.52
(53.9–74.2)
>0.415
  1. Gn Gender, Ag Age, Smk Smoking history
  2. aLogistic regression models were elaborated including the 177 patients with data on MMP-1, MMP-7 and MMP-9, and information on gender, age and smoking variables
  3. bSensitivity and specificity calculated based on Youden Index