Skip to main content

Table 5 Comparison of Diagnostic Performance of MMP-9 and its Combination with MMP-1 and/or MMP-7 for Non-Small Cell Lung Cancer Detection

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Modela

AUC

Sensitivity %

(95% CI)b

Specificity %

(95% CI) b

Youden Index

MMP-9 + Gn + Ag + Smk

0.787 (0.720–0.845)

85.54

(76.1–92.3)

64.89

(54.4–74.5)

>0.419

MMP-9 + MMP-1 + Gn + Ag + Smk

0.787 (0.720–0.845)

85.54

(76.1–92.3)

64.89

(54.4–74.5)

>0.421

MMP-9 + MMP-7 + Gn + Ag + Smk

0.786 (0.718–0.844)

81.93

(72–89.5)

64.52

(53.9–74.2)

>0.413

MMP-9 + MMP-1 + MMP-7 + Gn + Ag + Smk

0.788 (0.720–0.845)

81.93

(72–89.5)

64.52

(53.9–74.2)

>0.415

  1. Gn Gender, Ag Age, Smk Smoking history
  2. aLogistic regression models were elaborated including the 177 patients with data on MMP-1, MMP-7 and MMP-9, and information on gender, age and smoking variables
  3. bSensitivity and specificity calculated based on Youden Index