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Table 4 Serum Levels of MMP-1, −7 and −9 in Non-Small Cell Lung Cancer and Controls

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Markera

Median

Range

P b

AUC (95% CI)

MMP-1 (pg/mL)

 Control

6209.72

935.32–23,960.37

0.364

0.538 (0.457–0.620)

  Healthy

4730.11

1081.81–23,635.33

0.045

 

  Benign

7483.33

935.32–23,960.37

0.974

 

 NSCLC

6653.85

1450.34–41,668.33

  

  NSCLC I + II

6046.96

1784.41–30,180.33

0.772

 

  NSCLC III + IV

6972.73

1450.34–41,668.33

0.324

 

MMP-7 (pg/mL)

 Control

22,130.10

5026.14–79,977.27

0.014

0.604 (0.523–0.685)

  Healthy

21,010.07

8893.61–48,743.79

0.004

 

  Benign

22,739.58

5026.14–79,977.27

0.109

 

 NSCLC

26,485.45

5383.18–79,809.13

  

  NSCLC I + II

26,165.87

13,727.30–54,573.51

0.465

 

  NSCLC III + IV

26,680.26

5383.18–79,809.13

0.007

 

MMP-9 (ng/mL)

 Control

194.84

11.07–3611.59

<0.001

0.739 (0.670–0.809)

  Healthy

177.86

52.79–800.30

<0.001

 

  Benign

200.28

11.07–3611.59

<0.001

 

 NSCLC

348.04

21.06–1941.08

  

  NSCLC I + II

346.03

116.92–1941.08

0.002

 

  NSCLC III + IV

364.62

21.06–1914.00

<0.001

 
  1. NSCLC Non-Small Cell Lung Cancer
  2. aSample size: Control N = 110 (Healthy N = 35, Benign N = 75), NSCLC N = 83 (NSCLC I + II N = 24, NSCLC III + IV N = 59)
  3. bMann-Whitney U test for the comparison between the cancer and control groups, for subtypes of controls versus NSCLC, and NSCLC stages versus all controls