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Table 4 Serum Levels of MMP-1, −7 and −9 in Non-Small Cell Lung Cancer and Controls

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Markera Median Range P b AUC (95% CI)
MMP-1 (pg/mL)
 Control 6209.72 935.32–23,960.37 0.364 0.538 (0.457–0.620)
  Healthy 4730.11 1081.81–23,635.33 0.045  
  Benign 7483.33 935.32–23,960.37 0.974  
 NSCLC 6653.85 1450.34–41,668.33   
  NSCLC I + II 6046.96 1784.41–30,180.33 0.772  
  NSCLC III + IV 6972.73 1450.34–41,668.33 0.324  
MMP-7 (pg/mL)
 Control 22,130.10 5026.14–79,977.27 0.014 0.604 (0.523–0.685)
  Healthy 21,010.07 8893.61–48,743.79 0.004  
  Benign 22,739.58 5026.14–79,977.27 0.109  
 NSCLC 26,485.45 5383.18–79,809.13   
  NSCLC I + II 26,165.87 13,727.30–54,573.51 0.465  
  NSCLC III + IV 26,680.26 5383.18–79,809.13 0.007  
MMP-9 (ng/mL)
 Control 194.84 11.07–3611.59 <0.001 0.739 (0.670–0.809)
  Healthy 177.86 52.79–800.30 <0.001  
  Benign 200.28 11.07–3611.59 <0.001  
 NSCLC 348.04 21.06–1941.08   
  NSCLC I + II 346.03 116.92–1941.08 0.002  
  NSCLC III + IV 364.62 21.06–1914.00 <0.001  
  1. NSCLC Non-Small Cell Lung Cancer
  2. aSample size: Control N = 110 (Healthy N = 35, Benign N = 75), NSCLC N = 83 (NSCLC I + II N = 24, NSCLC III + IV N = 59)
  3. bMann-Whitney U test for the comparison between the cancer and control groups, for subtypes of controls versus NSCLC, and NSCLC stages versus all controls