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Table 2 Serum Levels of MMPs and TIMP-1 in Non-Small Cell Lung Cancer and Healthy Controls in the Initial Study Set

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Markera Median Range P b AUC (95% CI)
MMP-1 (pg/mL)
 Healthy 4504.00 1186.61–16,751.12 0.015 0.729 (0.560–0.897)
 NSCLC 8739.00 2517.57–20,715.00   
MMP-2 (pg/mL)
 Healthy 84,644.00 76,006.00–117,129.00 0.584 0.446 (0.251–0.641)
 NSCLC 85,643.00 60,249.00–144,375.00   
MMP-7 (pg/mL)
 Healthy 16,964.00 11,409.14–27,067.99 0.120 0.658 (0.473–0.843)
 NSCLC 20,742.11 7256.00–50,354.00   
MMP-9 (ng/mL)
 Healthy 136.14 63.13–492.91 <0.001 0.852 (0.725–0.979)
 NSCLC 302.92 131.16–824.08   
MMP-10 (pg/mL)
 Healthy 350.00 132.00–993.00 0.533 0.564 (0.355–0.774)
 NSCLC 400.00 209.00–730.00   
TIMP-1 (ng/mL)
 Healthy 130.45 92.40–238.90 0.191 0.625 (0.443–0.806)
 NSCLC 151.65 110.05–241.00   
MMP-9/TIMP1
 Healthy 1.09 0.51–5-05 0.002 0.781 (0.628–0.934)
 NSCLC 2.42 0.73–4.80   
  1. NSCLC Non-Small Cell Lung Cancer
  2. aSample size: Healthy N = 19, NSCLC N = 19
  3. bMann-Whitney U test for the comparison between cancer and healthy group