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Table 2 Serum Levels of MMPs and TIMP-1 in Non-Small Cell Lung Cancer and Healthy Controls in the Initial Study Set

From: Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis

Markera

Median

Range

P b

AUC (95% CI)

MMP-1 (pg/mL)

 Healthy

4504.00

1186.61–16,751.12

0.015

0.729 (0.560–0.897)

 NSCLC

8739.00

2517.57–20,715.00

  

MMP-2 (pg/mL)

 Healthy

84,644.00

76,006.00–117,129.00

0.584

0.446 (0.251–0.641)

 NSCLC

85,643.00

60,249.00–144,375.00

  

MMP-7 (pg/mL)

 Healthy

16,964.00

11,409.14–27,067.99

0.120

0.658 (0.473–0.843)

 NSCLC

20,742.11

7256.00–50,354.00

  

MMP-9 (ng/mL)

 Healthy

136.14

63.13–492.91

<0.001

0.852 (0.725–0.979)

 NSCLC

302.92

131.16–824.08

  

MMP-10 (pg/mL)

 Healthy

350.00

132.00–993.00

0.533

0.564 (0.355–0.774)

 NSCLC

400.00

209.00–730.00

  

TIMP-1 (ng/mL)

 Healthy

130.45

92.40–238.90

0.191

0.625 (0.443–0.806)

 NSCLC

151.65

110.05–241.00

  

MMP-9/TIMP1

 Healthy

1.09

0.51–5-05

0.002

0.781 (0.628–0.934)

 NSCLC

2.42

0.73–4.80

  
  1. NSCLC Non-Small Cell Lung Cancer
  2. aSample size: Healthy N = 19, NSCLC N = 19
  3. bMann-Whitney U test for the comparison between cancer and healthy group