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Table 3 Multivariable adjusted association of mammographic density measures with invasive ductal carcinoma and ductal carcinoma in situ

From: Comparison of the association of mammographic density and clinical factors with ductal carcinoma in situ versus invasive ductal breast cancer in Korean women

 

Invasive ductal cancer

Ductal carcinoma in situ

 

Number, Cases/controls

OR (95% CI)*

P value

Number, Cases/controls

OR (95% CI)*

P value

Total area (cm2) †

      

 Q1 (< 71.2985)

95/220

1

 

23/52

1

 

 Q2 (71.2985–89.9320)

94/225

0.99(0.74,1.33)

0.957

23/47

1.42(0.75,2.72)

0.285

 Q3 (89.9321–111.8983)

121/235

0.98(0.73,1.31)

0.981

28/37

1.93(0.96,3.90)

0.067

 Q4 (111.8984 ≤)

162/232

1.17(0.86,1.58)

0.319

16/40

1.79(0.78,4.11)

0.171

 1-quartile increase

472/912

1.05(0.95,1.16)

0.323

90/176

1.24(0.96,1.61)

0.095

P for Interaction§ = 0.998

Absolute dense area (cm2) †

      

 Q1 (< 8.09656)

82/230

1

 

19/42

1

 

 Q2 (8.09656–14.46536)

107/217

1.27(0.94,1.72)

0.116

14/55

0.59(0.27,1.28)

0.184

 Q3 (14.46537–22.46433)

113/225

1.23(0.91,1.68)

0.176

32/47

1.11(0.54,2.27)

0.780

 Q4 (22.46434 ≤)

170/240

1.41(1.05,1.90)

0.022

25/32

1.35(0.64,2.83)

0.434

 1-quartile increase

472/912

1.10(1.01,1.21)

0.039

90/176

1.17(0.91,1.50)

0.218

P for Interaction§ = 0.426

Non-dense area (cm2)†

      

 Q1 (< 54.8846)

109/219

1

 

31/53

1

 

 Q2 (54.8846–70.4895)

92/231

0.87(0.65,1.16)

0.330

20/41

1.41(0.73,2.72)

0.306

 Q3 (70.4896–93.2822)

120/236

0.93(0.70,1.24)

0.618

22/36

1.74(0.84,3.61)

0.134

 Q4 (93.2823 ≤)

151/226

1.03(0.75,1.41)

0.849

17/46

1.48(0.62,3.49)

0.376

 1-quartile increase

472/912

1.02(0.92,1.13)

0.747

90/176

1.17(0.90,1.53)

0.251

P for Interaction§ = 0.693

Percentage dense area ‡

      

 < 10%

98/248

1

 

21/48

1

 

 10–19%

151/285

1.29(0.97,1.70)

0.076

17/60

0.68(0.33,1.43)

0.310

 20–29%

116/219

1.37(1.01,1.85)

0.044

32/42

1.19(0.58,2.45)

0.641

 30–39%

62/98

1.36(0.95,1.95)

0.095

7/24

0.55(0.19,1.58)

0.267

 ≥ 40%

45/62

1.54(1.02,2.31)

0.039

13/2

1.90(0.72,5.06)

0.197

 10% increase

472/912

1.10(1.01,1.19)

0.029

90/176

1.11(0.90,1.37)

0.348

P for Interaction§ = 0.666

  1. *Odd ratio (OR) and 95% confidence intervals (CI) were estimated by conditional logistic regression analysis after adjusting for age, menopausal status, height, body mass index, age at menarche, number of children, ever smoking status, alcohol consumption, regular physical exercise, family history of breast cancer among first degree relatives, past history of benign breast disease, use of estrogen replacement, and the method of recruiting subjects
  2. †Quartiles (Q) were determined based on the distribution of mammographic measures of control group. Q1 is the lowest quartile level and Q4 is the highest quartile level
  3. ‡Calculated as the dense area divided by total breast area
  4. §Estimated by putting interaction term (unit of increase in each mammographic density measure X invasiveness) in the conditional logistic regression model after adjusting for covariates
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BMC Cancer

ISSN: 1471-2407

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