Fig. 5

EMT-dynamic genes reveal EMT periods of TCGA lung cancer patients. a The PCA plots show the PC1 and PC2 coefficients of 522 TCGA LUAD patients using their TCGA gene expression data for three gene sets: 254 EMT-dynamic genes (left), 76 previously identified ETM genes (top right) and all ~18,000 genes (top bottom). The dots are patients. The colors denote the patients personalized EMT periods (PEPs) in H358 (Methods): green (h0-8), brown (h16-24), purple (h72), magenta (h168) and yellow (>h500). b To evaluate how well TCGA LUAD patients are clustered on Panel A using three gene sets, the boxplots show the silhouette value distributions. The 254 EMT-dynamic genes have significantly higher silhouette values than others. c The personalized EMT periods (PEPs) of 522 TCGA LUAD patients significantly classify the patient survival rates by the Kaplan–Meier analysis. Three major PEP groups are h16 (red), h168 (green) and h72 (blue). The reference group of hazard ratios consists of the patients whose PEPs is h0-8