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Fig. 6 | BMC Cancer

Fig. 6

From: Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

Fig. 6

Signaling axis mediated by PKCα enhances cellular migration and invasion. In cells without PKCα expression (left), p120-catenin binds to the cytoplasmic domain of E-cadherin and stabilizes the AJs. In endocrine resistant ER+ breast cancer and basal A TNBC (right), PKCα increases FOXC2 expression and promotes its repression of p120-catenin transcription. As a result, E-cadherin is destabilized and prone to degradation, leading to dissociation of the AJ and intercellular connections

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BMC Cancer

ISSN: 1471-2407

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