Haematological cancer | Solid cancer | |||||||
---|---|---|---|---|---|---|---|---|
Unadjusted analysis | Adjusted analysisb | Unadjusted analysis | Adjusted analysisb | |||||
OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | |
Age in years | 1.02 (0.99–1.05) | 0.069 | – | – | 1.02 (1.01–1.04) | 0.006 | 1.02 (1.01–1.04) | 0.014 |
Gender male | 1.30 (0.69–2.44) | 0.411 | – | – | 0.72 (0.47–1.11) | 0.133 | – | – |
Alcohol consumption above guidance | 0.92 (0.27–3.09) | 0.894 | – | – | 1.40 (0.69–2.87) | 0.351 | – | – |
Former/current smoker yes | 0.92 (0.47–1.81) | 0.816 | – | – | 1.46 (0.91–2.35) | 0.120 | – | – |
Symptoms | – | |||||||
Weight loss | 0.56 (0.27–1.14) | 0.109 | – | – | 1.09 (0.70–1.69) | 0.698 | – | – |
Fatigue | 0.80 (0.41–1.58) | 0.522 | – | – | 0.86 (0.55–1.35) | 0.511 | – | – |
Loss of appetite | 0.31 (0.11–0.88) | 0.028 | 0.17 (0.04–0.71) | 0.015 | 1.63 (1.03–2.57) | 0.036 | 1.52 (0.93–2.50) | 0.097 |
Abdominal pain | 0.36 (0.11–1.19) | 0.094 | – | – | 1.99 (1.22–3.25) | 0.006 | 2.39 (1.42–4.06) | 0.001 |
Indefinable pain | 1.50 (0.72–3.16) | 0.281 | – | – | 1.03 (0.59–1.78) | 0.926 | – | – |
Night sweats | 0.34 (0.10–1.13) | 0.079 | – | – | 0.81 (0.45–1.44) | 0.465 | – | – |
General illness | 0.43 (0.13–1.40) | 0.159 | – | – | 1.09 (0.61–1.94) | 0.769 | – | – |
Fever | 0.61 (0.14–2.58) | 0.499 | – | – | 0.48 (0.17–1.36) | 0.169 | – | – |
Other | 0.86 (0.29–2.46) | 0.771 | – | – | 1.41 (0.76–2.59 | 0.276 | – | – |
Basic Biochemistryc | ||||||||
Anemia | 2.72 (1.43–5.18) | 0.002 | 2.36 (1.09–5.08) | 0.029 | 1.11 (0.69–1.78) | 0.669 | – | – |
Leukopenia | 11.69 (3.69–37.00) | <0.001 | 6.98 (1.69–28.69) | 0.007 | –d | 0.987 | – | – |
Leukocytosis | 1.26 (0.62–2.59) | 0.521 | – | – | 2.76 (1.79–4.26) | <0.001 | 2.19 (1.35–3.55) | 0.001 |
Thrombocytopenia | 6.52 (2.83–15.01) | <0.001 | 7.80 (3.19–19.10) | <0.001 | 1.53 (0.62–3.76) | 0.359 | – | – |
Thrombocytosis | 0.85 (0.29–2.48) | 0.767 | – | – | 2.27 (1.35–3.84) | 0.002 | 1.93 (1.06–3.51) | 0.032 |
Elevated ESRe | 1.26 (0.49–3.21) | 0.622 | – | – | 2.02 (1.06–3.87) | 0.033 | 1.35 (0.66–2.75) | 0.406 |
Elevated LDHf | 1.64 (0.86–3.15) | 0.137 | – | – | 1.88 (1.21–2.93) | 0.005 | 1.51 (0.92–2.48) | 0.100 |
Elevated CRPg | 1.63 (0.84–3.14) | 0.147 | – | – | 3.00 (1.93–4.67) | <0.001 | 2.91 (1.76–4.80) | <0.001 |