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Table 4 Sensitivity analysis - Predictors of solid and haematological cancer within one-yeara

From: Characteristics and outcome in patients with non-specific symptoms and signs of cancer referred to a fast track cancer patient pathway; a retrospective cohort study

  Haematological cancer Solid cancer
  Unadjusted analysis Adjusted analysisb Unadjusted analysis Adjusted analysisb
OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value
Age in years 1.02 (0.99–1.05) 0.069 1.02 (1.01–1.04) 0.006 1.02 (1.01–1.04) 0.014
Gender male 1.30 (0.69–2.44) 0.411 0.72 (0.47–1.11) 0.133
Alcohol consumption above guidance 0.92 (0.27–3.09) 0.894 1.40 (0.69–2.87) 0.351
Former/current smoker yes 0.92 (0.47–1.81) 0.816 1.46 (0.91–2.35) 0.120
Symptoms        
 Weight loss 0.56 (0.27–1.14) 0.109 1.09 (0.70–1.69) 0.698
 Fatigue 0.80 (0.41–1.58) 0.522 0.86 (0.55–1.35) 0.511
 Loss of appetite 0.31 (0.11–0.88) 0.028 0.17 (0.04–0.71) 0.015 1.63 (1.03–2.57) 0.036 1.52 (0.93–2.50) 0.097
 Abdominal pain 0.36 (0.11–1.19) 0.094 1.99 (1.22–3.25) 0.006 2.39 (1.42–4.06) 0.001
 Indefinable pain 1.50 (0.72–3.16) 0.281 1.03 (0.59–1.78) 0.926
 Night sweats 0.34 (0.10–1.13) 0.079 0.81 (0.45–1.44) 0.465
 General illness 0.43 (0.13–1.40) 0.159 1.09 (0.61–1.94) 0.769
 Fever 0.61 (0.14–2.58) 0.499 0.48 (0.17–1.36) 0.169
 Other 0.86 (0.29–2.46) 0.771 1.41 (0.76–2.59 0.276
Basic Biochemistryc
 Anemia 2.72 (1.43–5.18) 0.002 2.36 (1.09–5.08) 0.029 1.11 (0.69–1.78) 0.669
 Leukopenia 11.69 (3.69–37.00) <0.001 6.98 (1.69–28.69) 0.007 d 0.987
 Leukocytosis 1.26 (0.62–2.59) 0.521 2.76 (1.79–4.26) <0.001 2.19 (1.35–3.55) 0.001
 Thrombocytopenia 6.52 (2.83–15.01) <0.001 7.80 (3.19–19.10) <0.001 1.53 (0.62–3.76) 0.359
 Thrombocytosis 0.85 (0.29–2.48) 0.767 2.27 (1.35–3.84) 0.002 1.93 (1.06–3.51) 0.032
 Elevated ESRe 1.26 (0.49–3.21) 0.622 2.02 (1.06–3.87) 0.033 1.35 (0.66–2.75) 0.406
 Elevated LDHf 1.64 (0.86–3.15) 0.137 1.88 (1.21–2.93) 0.005 1.51 (0.92–2.48) 0.100
 Elevated CRPg 1.63 (0.84–3.14) 0.147 3.00 (1.93–4.67) <0.001 2.91 (1.76–4.80) <0.001
  1. aWithin one year of ended investigational course at the NSSC-CPP bMultivariate analysis adjusted for age, gender, smoking status and alcohol consumption. cReferences are given in Table 3. dLeukopenia were so rarely seen in patients with solid cancer making it impossible to estimate OR. e ESR Erythrocyte Sedimentation Ratio. f LDH Lactate dehydrogenase. g CRP C-reactive protein