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Table 4 Sensitivity analysis - Predictors of solid and haematological cancer within one-yeara

From: Characteristics and outcome in patients with non-specific symptoms and signs of cancer referred to a fast track cancer patient pathway; a retrospective cohort study

 

Haematological cancer

Solid cancer

 

Unadjusted analysis

Adjusted analysisb

Unadjusted analysis

Adjusted analysisb

OR (95%CI)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

OR (95%CI)

P-value

Age in years

1.02 (0.99–1.05)

0.069

1.02 (1.01–1.04)

0.006

1.02 (1.01–1.04)

0.014

Gender male

1.30 (0.69–2.44)

0.411

0.72 (0.47–1.11)

0.133

Alcohol consumption above guidance

0.92 (0.27–3.09)

0.894

1.40 (0.69–2.87)

0.351

Former/current smoker yes

0.92 (0.47–1.81)

0.816

1.46 (0.91–2.35)

0.120

Symptoms

       

 Weight loss

0.56 (0.27–1.14)

0.109

1.09 (0.70–1.69)

0.698

 Fatigue

0.80 (0.41–1.58)

0.522

0.86 (0.55–1.35)

0.511

 Loss of appetite

0.31 (0.11–0.88)

0.028

0.17 (0.04–0.71)

0.015

1.63 (1.03–2.57)

0.036

1.52 (0.93–2.50)

0.097

 Abdominal pain

0.36 (0.11–1.19)

0.094

1.99 (1.22–3.25)

0.006

2.39 (1.42–4.06)

0.001

 Indefinable pain

1.50 (0.72–3.16)

0.281

1.03 (0.59–1.78)

0.926

 Night sweats

0.34 (0.10–1.13)

0.079

0.81 (0.45–1.44)

0.465

 General illness

0.43 (0.13–1.40)

0.159

1.09 (0.61–1.94)

0.769

 Fever

0.61 (0.14–2.58)

0.499

0.48 (0.17–1.36)

0.169

 Other

0.86 (0.29–2.46)

0.771

1.41 (0.76–2.59

0.276

Basic Biochemistryc

 Anemia

2.72 (1.43–5.18)

0.002

2.36 (1.09–5.08)

0.029

1.11 (0.69–1.78)

0.669

 Leukopenia

11.69 (3.69–37.00)

<0.001

6.98 (1.69–28.69)

0.007

d

0.987

 Leukocytosis

1.26 (0.62–2.59)

0.521

2.76 (1.79–4.26)

<0.001

2.19 (1.35–3.55)

0.001

 Thrombocytopenia

6.52 (2.83–15.01)

<0.001

7.80 (3.19–19.10)

<0.001

1.53 (0.62–3.76)

0.359

 Thrombocytosis

0.85 (0.29–2.48)

0.767

2.27 (1.35–3.84)

0.002

1.93 (1.06–3.51)

0.032

 Elevated ESRe

1.26 (0.49–3.21)

0.622

2.02 (1.06–3.87)

0.033

1.35 (0.66–2.75)

0.406

 Elevated LDHf

1.64 (0.86–3.15)

0.137

1.88 (1.21–2.93)

0.005

1.51 (0.92–2.48)

0.100

 Elevated CRPg

1.63 (0.84–3.14)

0.147

3.00 (1.93–4.67)

<0.001

2.91 (1.76–4.80)

<0.001

  1. aWithin one year of ended investigational course at the NSSC-CPP bMultivariate analysis adjusted for age, gender, smoking status and alcohol consumption. cReferences are given in Table 3. dLeukopenia were so rarely seen in patients with solid cancer making it impossible to estimate OR. e ESR Erythrocyte Sedimentation Ratio. f LDH Lactate dehydrogenase. g CRP C-reactive protein