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Table 3 Predictors of cancer diagnosis within one-yeara

From: Characteristics and outcome in patients with non-specific symptoms and signs of cancer referred to a fast track cancer patient pathway; a retrospective cohort study

  Unadjusted analysis Adjusted analysisb
OR (95%CI) P-value OR (95% CI) P-value
Age in years 1.03 (1.01–1.04) <0.001 1.03 (1.01–1.04) 0.002
Gender male 0.86 (0.59–1.24) 0.414
Alcohol consumption above guidance 1.27 (0.67–2.40) 0.467
Former/current smoker yes 1.29 (0.86–1.92) 0.223
Symptoms
 Weight loss 0.89 (0.61–1.31) 0.549
 Fatigue 0.83 (0.56–1.23) 0.348
 Loss of appetite 1.11 (0.73–1.68) 0.626
 Abdominal pain 1.39 (0.88–2.18) 0.158
 Indefinable pain 1.18 (0.75–1.87) 0.479
 Night sweats 0.63 (0.37–1.08) 0.092
 General illness 0.86 (0.50–1.45) 0.560
 Fever 0.50 (0.21–1.18) 0.114
 Other 1.24 (0.72–2.16) 0.440
Abnormal biochemistry levels
 Anemia <7.3 for women
<8.3 for men
1.56 (1.05–2.31) 0.028 1.63 (1.02–2.60) 0.040
 Leucocytopenia <3.5 × 109 3.45 (1.15–10.39) 0.028 2.01 (0.52–7.74) 0.311
 Leucocytosis >8.8 × 109 2.38 (1.62–3.50) <0.001 2.06 (1.34–3.15) <0.001
 Thrombocytopenia <145 × 109 3.47 (1.77–6.81) <0.001 4.13 (2.02–8.47) <0.001
 Thrombocytosis >390 × 109 1.89 (1.16–3.07) 0.010 1.67 (0.96–2.91) 0.071
 Elevated ESRc >15 1.82 (1.05–3.15) 0.033 1.29 (0.70–2.37) 0.411
 Elevated LDHd > 205 U/l 1.90 (1.30–2.79) 0.001 1.64 (1.07–2.52) 0.023
 Elevated CRPe >10 mg/l 2.70 (1.84–3.97) <0.001 2.56 (1.66–3.95) <0.001
  1. aWithin one year of ended investigational course at the NSSC-CPP bMultivariate analysis adjusted for age, gender, smoking status and alcohol consumption. c ESR Erythrocyte Sedimentation Ratio. d LDH Lactate dehydrogenase. e CRP C-reactive protein