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Table 1 Summary of the phenotypic evaluation of cetuximab sensitivity of gastric cancer cell lines using different assays

From: Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis

Cell line Proliferationa Motilityb Invasionc
Viabilityd Motile cells (%)e Average speede Invasive cellse
MKN1 ++ + +
  1. adetermined via XTT cell proliferation assay as previously published by Kneissl et al. [7]
  2. bdetermined via time-lapse microscopy
  3. cdetermined via Matrigel invasion assay
  4. d- = not detectable; +/++/+++ = detectable at low/intermediate/high levels as previously published by Kneissl et al. [7]
  5. e + = EGF-induced increases and significant reversions by EGF/cetuximab treatment at a significance level of at least ≤0.050