| |
Odds ratio
|
95% confidence interval
|
p-value
|
|---|
|
Univariate analysis
|
|
Age
|
0.93
|
0.722–1.20
|
0.575
|
|
ECOG Performance status = 2
|
0.449
|
0.100–2.01
|
0.295
|
|
Brinkman Index
|
1.00
|
0.999–1.00
|
0.655
|
|
Emphysema
|
0.794
|
0.112–5.66
|
0.818
|
|
Diabetes melitus
|
2.23
|
0.497–10.0
|
0.295
|
|
Squamous cell carcinoma
|
0.889
|
0.135–5.85
|
0.902
|
|
Major diameter of the primary site
|
1.01
|
0.973–1.04
|
0.672
|
|
Brain metastasis
|
2.12
|
0.349–13.0
|
0.414
|
|
Bone metastasis
|
9.92
|
1.75–56.3
|
0.00961
|
|
Liver metastasis
|
0.900
|
0.0723–11.2
|
0.935
|
|
Adrenal gland metastasis
|
7.12
|
0.640–79.3
|
0.110
|
|
Carboplatin-based doublet therapy
|
1.06
|
0.229–4.92
|
0.939
|
|
Lymphocyte count
|
1
|
0.999–1.00
|
0.866
|
|
Hemoglobin
|
0.637
|
0.392–1.04
|
0.0691
|
|
Albumin
|
0.117
|
0.0168–0.811
|
0.0299
|
|
Lactate dehydrogenase
|
1.01
|
0.999–1.02
|
0.0979
|
|
Calcium
|
1.19
|
0.632–2.24
|
0.59
|
|
C-reactive protein
|
1.15
|
0.897–1.48
|
0.267
|
|
Multivariate analysis
|
|
Bone metastasis
|
10.9
|
1.52–77.9
|
0.0174
|
|
Albumin
|
0.0886
|
0.00791–0.992
|
0.0493
|
- In the univariate analysis, serum albumin level and the existence of bone metastasis, all with p-values <0.05, were selected as candidate risk factors. A multivariate analysis showed that the association between serum albumin level and the existence of bone metastasis with early termination of chemotherapy were statistically significant
- Abbreviations: ECOG Eastern Cooperative Oncology Group
