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Table 3 Logistic regression analysis verifying the risk factors for early termination of chemotherapy (N = 31)

From: Serum albumin level as a potential marker for deciding chemotherapy or best supportive care in elderly, advanced non-small cell lung cancer patients with poor performance status

  Odds ratio 95% confidence interval p-value
Univariate analysis
 Age 0.93 0.722–1.20 0.575
 ECOG Performance status = 2 0.449 0.100–2.01 0.295
 Brinkman Index 1.00 0.999–1.00 0.655
 Emphysema 0.794 0.112–5.66 0.818
 Diabetes melitus 2.23 0.497–10.0 0.295
 Squamous cell carcinoma 0.889 0.135–5.85 0.902
 Major diameter of the primary site 1.01 0.973–1.04 0.672
 Brain metastasis 2.12 0.349–13.0 0.414
 Bone metastasis 9.92 1.75–56.3 0.00961
 Liver metastasis 0.900 0.0723–11.2 0.935
 Adrenal gland metastasis 7.12 0.640–79.3 0.110
 Carboplatin-based doublet therapy 1.06 0.229–4.92 0.939
 Lymphocyte count 1 0.999–1.00 0.866
 Hemoglobin 0.637 0.392–1.04 0.0691
 Albumin 0.117 0.0168–0.811 0.0299
 Lactate dehydrogenase 1.01 0.999–1.02 0.0979
 Calcium 1.19 0.632–2.24 0.59
 C-reactive protein 1.15 0.897–1.48 0.267
Multivariate analysis
 Bone metastasis 10.9 1.52–77.9 0.0174
 Albumin 0.0886 0.00791–0.992 0.0493
  1. In the univariate analysis, serum albumin level and the existence of bone metastasis, all with p-values <0.05, were selected as candidate risk factors. A multivariate analysis showed that the association between serum albumin level and the existence of bone metastasis with early termination of chemotherapy were statistically significant
  2. Abbreviations: ECOG Eastern Cooperative Oncology Group