Fig. 4

Survival outcomes in relation to IGF1R and/or SphK1 protein expression in hormone therapy treated breast cancer patients. Kaplan-Meier analysis was performed to measure the overall survival (OS) for (a). hormone therapy (anti-endocrine therapy) treatment (non-stratified) and further stratified for high vs. low (b). IGF1R (c). IGF1R and SphK1 co-expression and (d). SphK1 expression as described under Methods. Statistical significance was accepted as a log-rank p-value <0.05