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Table 1 Estimated prevalence of incidental breast cancer and precursor lesions by year of autopsies done and thoroughness of examination in the 13 included studies

From: Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis

Author

Median year autopsies done

Country/Ethnicity

Number of women

Age (range, years)

Study Population

Peer Review

Used international pathology reporting method

Detected breast cancer possibly caused woman’s death?

Mean number of sections submitted for pathology

Invasive Cancera

In-situ cancer (DCISb/LCIS)c

Atypical Hyperplasia (ADHd/ALH)e

All categories of Cancer or Precursor lesiona

Forensic vs Hospital

Consecutive

Kiaer

1948

Denmark

351

51

Forensic

No

No

No

No

Not available

0·3%

0·0%

0·0%

0·3%

(16–89)

Ryan

1962

Canada

100

56

Hospital

No

Yes

No

Not available

7

0·0%

0·0%

3·0%

3·0%

Sarnelli

1962

Italy

100

62

Hospital

No

No

Yes

No

Not available

0·0%

0·0%

0·0%

0·0%

(46–90)

Kramer

1973

USA

70

79

Hospital

No

No

No

Not available

100

1·4%

4·3%

10·0%

15·7%

(70 –?)

Nielsen 1984

1977

Denmark

75

67

Hospital

Yes

No

Yes: WHO (1981), Azzopardi

No

189

1·3%

18·7%

4·0%

26·6%

(22–89)

Bartow

1981

USA

519

43

Forensic

Yes

No

No

No

18

1·0%

0·4%

1·0%

2·3%

(15–88)

Nielsen 1987

1984

Denmark

109

39

Forensic

Yes

No

Yes: WHO (1981), Azzopardi

No

549

0·9%

18·3%

7·3%

26·6%

(20–54)

Alpers

1985

USA

101

51

Hospital

No

No

No

No

253

0·0%

8·9%

10·9%

19·8%

(15–99)

Pisano

1985

Chile

152

44

Forensic

No

Yes

Yes

No

3

0·7%

0·0%

0·0%

0·7%

Bhathal

1985

Australia

207

60

Forensic

Yes

No

Yes: Black & de Chabon

No

23

1·4%

13·0%

12·6%

27·1%

(15–97)

Giarelli

1985

Italy

463

77

Hospital

Yes

No

No

No

Not available

1·5%

0·0%

0·0%

1·5%

(35 –?)

Inai

1985

Japan

62

55

Hospital

No

No

Yes: Azzopardi

No

36

1·6%

0·0%

14·5%

16·1%

(11–85)

Starlsberg (Ghana)f

2010

  

39

Hospital

No

Yes

No

Yes

8

7·1%

0·0%

0·0%

7·1%

Ghana

28

(15–60)

Starlsberg (Norway)f

2010

  

42

Hospital

No

Yes

No

Yes

8

3·8%

0·0%

3·8%

7·7%

Norway

26

(15–60)

  1. aPrevalences may differ to those reported in primary studies due to exclusion of cases which may have been diagnosed during life
  2. b DCIS Ductal carcinoma in-situ
  3. c LCIS Lobular Carcinoma in-situ
  4. d ADH Atypical Ductal Hyperplasia
  5. e ALH Atypical Lobular Hyperplasia
  6. fIn Stalsberg study, two women with invasive breast cancer first diagnosed at autopsy died of cardiac tamponade/massive pleural effusion and metastatic signet cell carcinoma (the women were from Ghana and Norway respectively)