Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients

Table 4 Analysis with the revised Bethesda criteria

	<50 N = 31	≥50 N = 112
HNPCC	N = 5	N = 1
Meeting revised Bethesda criteria #1	5	0
Meeting revised Bethesda criteria #2	0	0
Meeting revised Bethesda criteria #3	4^a	0
Meeting revised Bethesda criteria #4	2	1
Meeting revised Bethesda criteria #5	1	0
Amsterdam criteria met	0	0
Non-HNPCC or Sporadic	N = 26	N = 111
Meeting revised Bethesda criteria #1	26	0
Meeting revised Bethesda criteria #2	0	6
Meeting revised Bethesda criteria #3	2	0
Meeting revised Bethesda criteria #4	0	0
Meeting revised Bethesda criteria #5	1	1
Amsterdam criteria met	0	0

^aFour HNPCC patients diagnosed under age 50 show colorectal cancers with MSI-H history. The other HNPCC patient under age 50 did not have IHC or MSI testing
The revised Bethesda criteria: 1. Colorectal cancer diagnosed at less than 50 years of age. 2. Presence of synchronous, metachronous colorectal or other HNPCC associated tumors regardless of age. 3. Colorectal cancer with MSI-H history in a patient diagnosed at less than 60 years old. 4. Colorectal cancer diagnosed in one or more first degree relatives with an HNPCC related tumor with one of the cancers being diagnosed under age 50 years. 5. Colorectal cancer diagnosed in two or more first- or second-degree relatives with HNPCC-related tumors, regardless of age [16]

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