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Table 2 Univariate and multivariate analysis of patient- and treatment-related risk factors for neck muscle spasm

From: Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy

  P value OR (95% CI)
Univariate analysis
 Sex   
  Male   Ref
  Female 0.003 2.620 (1.387, 4.949)
 Age (years)
   ≤ 41   Ref
   > 41 0.472 1.250 (0.681, 2.297)
 T stage
  T1–2   Ref
  T3–4 0.358 1.440 (0.662, 3.131)
 N stage
  N0–1   Ref
  N2–3 0.002 2.846 (1.445, 5.607)
 Smoking status
  Yes 0.799 0.919 (0.481, 1.758)
  No   Ref
 Drinking status
  Yes 0.851 1.083 (0.472, 2.485)
  No   Ref
 Induction chemotherapy
  Yes 0.839 1.065 (0.581, 1.953)
  No   Ref
 Concurrent chemotherapy
  Yes 0.851 0.924 (0.402, 2.120)
  No   Ref
 Neck dissection
  Yes 0.332 1.963 (0.502, 7.671)
  No   Ref
 D mean < 0.001 1.002 (1.001, 1.003)
 D min < 0.001 1.001 (1.001, 1.001)
 D max 0.007 1.001 (1.000, 1.002)
 V20a < 0.001 1.085 (1.045, 1.127)
 V25 < 0.001 1.085 (1.046, 1.125)
 V30 < 0.001 1.083 (1.046, 1.121)
 V35 < 0.001 1.081 (1.045, 1.118)
 V40 < 0.001 1.082 (1.046, 1.120)
 V45 < 0.001 1.085 (1.048, 1.122)
 V50 < 0.001 1.118 (1.068, 1.171)
 V55 < 0.001 1.148 (1.096, 1.202)
 V60 < 0.001 1.192 (1.133, 1.255)
 V65 < 0.001 1.106 (1.076, 1.136)
 V70 < 0.001 1.126 (1.072, 1.183)
 V75 0.653 1.173 (0.585, 2.349)
 V80 0.999 0.000 (0.000, 0.000)
 D20b < 0.001 1.004 (1.003, 1.005)
 D25 < 0.001 1.005 (1.003, 1.006)
 D30 < 0.001 1.005 (1.003, 1.006)
 D35 < 0.001 1.005 (1.004, 1.007)
 D40 < 0.001 1.005 (1.004, 1.007)
 D45 < 0.001 1.005 (1.004, 1.007)
 D50 < 0.001 1.005 (1.003, 1.007)
 D55 < 0.001 1.003 (1.002, 1.005)
 D60 0.001 1.002 (1.001, 1.003)
 D65 0.001 1.001 (1.000, 1.002)
 D70 < 0.001 1.001 (1.000, 1.001)
 D75 < 0.001 1.001 (1.000, 1.001)
 D80 < 0.001 1.001 (1.000, 1.001)
Multivariate analysis
 Sex
  Male   Ref
  Female 0.024 3.044 (1.157, 8.012)
 N stage
  N0–1   Ref
  N2–3 0.035 2.823 (1.078, 7.398)
 V60 < 0.001 1.185 (1.126, 1.246)
  1. Abbreviations: Dmean mean dose to the sternocleidomastoid muscle, Dmax maximum dose to the sternocleidomastoid muscle, V20 a percentage of the sternocleidomastoid muscle volume that received >20 Gy, D20 b dose to 20% of the sternocleidomastoid muscle volume; other dosimetric parameters are reported in a similar manner