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Table 2 The distribution of genotypes and alleles of Arg399Gln of gene XRCC1, Arg72Pro of gene TP53 and T309G of gene MDM2 in BC patients of Kyrgyz ethnicity compared to healthy controls

From: The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females

Markers Alleles and genotypes Cases, n (%) Controls, n (%) χ2 р OR CI 95%
Arg399Gln
gene XRCC1
rs25487
Allele Arg399 144 (62) 146 (72) 4.46 0.034 0.64 0.42–0.95
Allele 399Gln 90 (38) 58 (28) 1.57 1.05–2.35
Arg399Arg 38 (32) 56 (55) 13.86 0.0010 0.39 0.22–0.68
Arg399Gln 68 (58) 34 (33) 2.77 1.60–4.80
Gln399Gln 11 (10) 12 (12) 0.77 0.32–1.84
HWE χ2 /р 6.07/0.01 3.33/0.06  
Arg72Pro
gene TP53
rs1042522
Allele Arg72 164 (70) 142 (70) 0.011 0.913 1.02 0.68–1.54
Allele 72Pro 70 (30) 62 (30) 0.98 0.65–1.47
Arg72Arg 57(49) 53 (52) 1.80 0.41 0.88 0.52–1.49
Arg72Pro 50 (43) 36 (35) 1.37 0.79–2.36
Pro 72Pro 10 (8) 13 (13) 0.64 0.27–1.53
HWE χ2 /р 0.04/0.83 2.80/0.09  
T309G
gene MDM2
rs2279744
Allele T309 120 (49) 111(46) 0.31 0.58 0.88 0.60–1.28
Allele 309G 114 (51) 93 (54) 1.13 0.77–1.65
G309G 29 (24) 28 (27) 0.500 0.77 0.87 0.47–1.59
T309G 62 (53) 55 (54) 0.96 0.56–1.64
T309 T 26 (22) 19 (18) 1.24 0.64–2.42
HWE χ2 /р 0.42/0.51 0.77/0.38  
  1. OR odds ratio, CI confidence interval, HWE Hardy-Weinberg equilibrium