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Table 2 The distribution of genotypes and alleles of Arg399Gln of gene XRCC1, Arg72Pro of gene TP53 and T309G of gene MDM2 in BC patients of Kyrgyz ethnicity compared to healthy controls

From: The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females

Markers

Alleles and genotypes

Cases, n (%)

Controls, n (%)

χ2

р

OR

CI 95%

Arg399Gln

gene XRCC1

rs25487

Allele Arg399

144 (62)

146 (72)

4.46

0.034

0.64

0.42–0.95

Allele 399Gln

90 (38)

58 (28)

1.57

1.05–2.35

Arg399Arg

38 (32)

56 (55)

13.86

0.0010

0.39

0.22–0.68

Arg399Gln

68 (58)

34 (33)

2.77

1.60–4.80

Gln399Gln

11 (10)

12 (12)

0.77

0.32–1.84

HWE χ2 /р

6.07/0.01

3.33/0.06

 

Arg72Pro

gene TP53

rs1042522

Allele Arg72

164 (70)

142 (70)

0.011

0.913

1.02

0.68–1.54

Allele 72Pro

70 (30)

62 (30)

0.98

0.65–1.47

Arg72Arg

57(49)

53 (52)

1.80

0.41

0.88

0.52–1.49

Arg72Pro

50 (43)

36 (35)

1.37

0.79–2.36

Pro 72Pro

10 (8)

13 (13)

0.64

0.27–1.53

HWE χ2 /р

0.04/0.83

2.80/0.09

 

T309G

gene MDM2

rs2279744

Allele T309

120 (49)

111(46)

0.31

0.58

0.88

0.60–1.28

Allele 309G

114 (51)

93 (54)

1.13

0.77–1.65

G309G

29 (24)

28 (27)

0.500

0.77

0.87

0.47–1.59

T309G

62 (53)

55 (54)

0.96

0.56–1.64

T309 T

26 (22)

19 (18)

1.24

0.64–2.42

HWE χ2 /р

0.42/0.51

0.77/0.38

 
  1. OR odds ratio, CI confidence interval, HWE Hardy-Weinberg equilibrium