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Table 3 Clinical response according to the genotype of TP53 SNP rs1042522

From: TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP

Response

Genotype

P

 

GG + GC (%)

CC (%)

All patients

 CR

196(61)

33(44)

0.007

 PR + PD + SD

125(38.9)

42(56)

 OR

276(86)

57(76)

0.033

 PD + SD

45(14)

18(24)

Patients without Rituximab

 CR

38(45.8)

3(12.5)

0.004a

 PR + PD + SD

45(54.2)

21(87.5)

 OR

69(83.1)

18(75)

0.368

 PD + SD

14(16.9)

6(25)

Patients with Rituximab

 CR

158(66.4)

30(58.8)

0.304

 PR + PD + SD

80(33.6)

21(41.2)

 OR

207(87)

39(76.5)

0.056

 PD + SD

31(13)

12(23.5)

  1. CR Complete response
  2. PR Partial response
  3. PD Progression disease
  4. SD Stable disease
  5. OR Overall response
  6. a:Fisher’s Exact Test