Fig. 7

Downregulation of miR-486-5p inhibits cervical cancer growth in vivo by targeting PTEN. The cervical cancer mouse model was constructed by injecting mice with HeLa cells transfected with control miRNA (Mock) or miR-486-5p inhibitor sponge (Inhibitor). a Mice were sacrificed on day 21 and their tumors removed and weighed and measured. b The volumes of the tumors from the two groups were calculated and compared. The tumor volume was calculated with the following formula: (Length × Width²) × 3.14/6. c The weights of the tumors from the two groups were compared. d The expression of PTEN in local tumor tissues was determined by immunohistochemistry (40×). Controls were stained with hematoxylin and eosin (H&E). The arrows show PTEN expression in local tumor tissues. *P < 0.05, compared to Mock