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Table 3 Univariate and multivariate survival analyses of OS and CSS in patients with colorectal cancer

From: The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer

Variable Overall survival Cancer-Specific Survival
Univariate Multivariate Univariate Multivariate
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age (y)   0.016   0.005   0.222   
 ≥60 1   1   1    
 <60 0.777 (0.632–0.955)   0.737 (0.597–0.910)   0.873 (0.702–1.086)    
Gender   0.011   0.003   0.084   
 Male 1   1   1    
 Female 0.766 (0.624–0.940)   0.730 (0.591–0.902)   0.825 (0.663–1.026)    
Tumor Size (cm)   0.397     0.354   
 ≥4.6 1     1    
 <4.6 0.917 (0.751–1.120)     0.904 (0.729–1.120)    
Tumor location   0.732     0.876   
 Colon 1     1    
 Rectum 1.036 (0.846–1.268)     1.017 (0.819–1.264)    
Differentiation   <0.001   0.001   <0.001   0.001
 Well - moderate 1   1   1   1  
 Poor - undifferentiated 2.438 (1.836–3.237)   1.647 (1.233–2.198)   2.621 (1.950–3.524)   1.644 (1.216–2.221)  
pT category   <0.001   <0.001   <0.001   <0.001
 T1 1   1   1   1  
 T2 1.596 (0.486–5.239)   1.390 (0.423–4.573)   0.996 (0.293–3.382)   0.825 (0.243–2.808)  
 T3 4.362 (1.393–13.665)   2.132 (0.677–6.715)   3.725 (1.187–11.691)   1.689 (0.534–5.338)  
 T4 6.353 (2.029–19.890)   2.910 (0.924–9.165)   5.670 (1.809–17.765)   2.416 (0.766–7.627)  
pN category   <0.001   <0.001   <0.001   <0.001
 pN0 1   1   1   1  
 pN1 4.779 (3.702–6.170)   4.132 (3.189–5.354)   5.678 (4.249–7.587)   4.856 (3.622–6.512)  
 pN2 11.353 (8.583–15.016)   10.215 (7.648–13.643)   14.388 (10.556–19.610)   11.760 (8.565–16.147)  
Distant metastasis   <0.001   0.001   <0.001   0.001
 Negative 1   1   1   1  
 Positive 3.690 (2.349–5.797)   2.226 (1.407–3.524)   3.974 (2.497–6.324)   2.200 (1.375–3.522)  
TNM stage   <0.001     <0.001   
 I 1     1    
 II 2.398 (1.327–4.332)     4.854 (1.944–12.118)    
 III 12.092 (6.931–21.097)     27.933 (11.524–67.709)    
 IV 20.970 (10.408–42.248)     50.019 (18.648–134.163)    
LMR   <0.001   0.698   0.001   0.663
 ≥5.8 1   1   1   1  
 <5.8 1.565 (1.239–1.976)   1.054 (0.809–1.373)   1.541 (1.201–1.977)   1.064 (0.804–1.409)  
NLR   <0.001   0.021   <0.001   0.018
 ≥2.0 1   1   1   1  
 <2.0 0.621 (0.508–0.760)   0.758 (0.598–0.960)   0.620 (0.499–0.770)   0.738 (0.573–0.950)  
PLR   0.001   0.239   <0.001   0.160
 ≥134.6 1   1   1   1  
 <134.6 0.710 (0.582–0.867)   0.873 (0.697–1.094)   0.652 (0.526–0.807)   0.841 (0.661–1.070)  
PNI   <0.001   0.084   <0.001   0.065
 ≥46.4 1   1   1   1  
 <46.4 1.503 (1.199–1.884)   1.238 (0.972–1.576)   1.552 (1.220–1.975)   1.272 (0.985–1.643)  
  1. Abbreviations: CI confidence interval, HR hazard ratio, LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, PNI prognostic nutritional index