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Table 2 Associations of clinicopathological features with LMR, NLR, PLR and PNI in colorectal cancer

From: The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer

Variable

LMR

NLR

PLR

PNI

<  5.8

≥  5.8

P

<  2.0

≥  2.0

P

<  134.6

≥  134.6

P

<  46.4

≥  46.4

P

Age(y)

  

0.086

  

0.001

  

0.556

  

< 0.001

 ≥ 60

700(58.7)

300(54.3)

 

499(53.7)

501(61.5)

 

588(57.9)

421(56.5)

 

233(68.1)

767(54.7)

 

 < 60

492(41.3)

252(45.7)

 

431(46.3)

313(38.5)

 

427(42.1)

317(43.5)

 

109(31.9)

635(45.3)

 

Gender

  

< 0.001

  

< 0.001

  

< 0.001

  

0.543

 Male

738(61.9)

244(44.2)

 

481(51.7)

501(61.5)

 

404(39.8)

371(50.9)

 

198(57.9)

784(55.9)

 

 Female

454(38.1)

308(55.8)

 

449(48.3)

313(38.5)

 

611(60.2)

358(49.1)

 

144(42.1)

618(44.1)

 

Tumor size (cm)

  

< 0.001

  

< 0.001

  

< 0.001

  

< 0.001

 ≥ 4.6

637(53.4)

238(43.1)

 

395(42.5)

480(59.0)

 

438(43.2)

437(59.9)

 

236(69.0)

639(45.6)

 

 < 4.6

555(46.6)

314(56.9)

 

535(57.5)

334(41.0)

 

577(56.8)

292(40.1)

 

106(31.0)

763(54.4)

 

Tumor location

  

< 0.001

  

0.073

  

< 0.001

  

< 0.001

 Colon

544(45.6)

196(35.5)

 

376(40.4)

364(44.7)

 

342(33.7)

398(54.6)

 

193(56.4)

547(39.0)

 

 Rectum

648(54.4)

356(64.5)

 

554(59.6)

450(55.3)

 

673(66.3)

331(45.4)

 

149(43.6)

855(61.0)

 

Differentiation

  

0.069

  

0.001

  

0.001

  

0.001

 Well - moderate

1086(91.1)

517(93.7)

 

873(93.9)

730(89.7)

 

952(93.8)

63(6.2)

 

299(87.4)

1304(93.0)

 

 Poor - undifferentiated

106(8.9)

35(6.3)

 

57(6.1)

84(10.3)

 

651(89.3)

78(10.7)

 

43(12.6)

98(7.0)

 

pT category

  

0.006

  

0.019

  

0.003

  

< 0.001

 T1

30(2.5)

22(4.0)

 

30(3.2)

22(2.7)

 

34(3.3)

18(2.5)

 

3(0.9)

49(3.5)

 

 T2

188(15.8)

119(21.6)

 

187(20.1)

120(14.7)

 

206(20.3)

101(13.9)

 

39(11.4)

268(19.1)

 

 T3

470(39.4)

197(35.7)

 

350(37.6)

317(38.9)

 

378(37.2)

289(39.6)

 

157(45.9)

510(36.4)

 

 T4

504(42.3)

214(38.8)

 

363(39.0)

355(43.6)

 

397(39.1)

321(44.0)

 

143(41.8)

575(41.0)

 

pN category

  

0.497

  

0.558

  

0.184

  

0.412

 pN0

689(57.8)

335(60.7)

 

557(59.9)

467(57.4)

 

611(60.2)

413(56.7)

 

194(56.7)

830(59.2)

 

 pN1

365(30.6)

160(29.0)

 

273(29.4)

252(31.0)

 

301(29.7)

224(30.7)

 

103(30.1)

422(30.1)

 

 pN2

138(11.6)

57(10.3)

 

100(10.8)

95(11.7)

 

103(10.1)

92(12.6)

 

45(13.2)

150(10.7)

 

Distant metastasis

  

0.130

  

0.947

  

0.577

  

0.337

 Negative

1161(97.4)

544(98.6)

 

909(97.7)

796(97.8)

 

994(97.9)

711(97.5)

 

332(97.1)

1373(97.9)

 

 Positive

31(2.6)

8(1.4)

 

21(2.3)

18(2.2)

 

21(2.1)

18(2.5)

 

10(2.9)

29(2.1)

 

TNM stage

  

0.018

  

0.026

  

0.010

  

0.001

 I

176(14.8)

112(20.3)

 

177(19.0)

111(13.6)

 

193(19.0)

95(13.0)

 

32(9.4)

256(18.3)

 

 II

505(42.4)

221(40.0)

 

376(40.4)

350(43.0)

 

415(40.9)

311(42.7)

 

158(46.2)

568(40.5)

 

 III

480(40.3)

211(38.2)

 

356(38.3)

335(41.2)

 

386(38.0)

305(41.8)

 

142(41.5)

549(39.2)

 

 IV

31(2.6)

8(1.4)

 

21(2.3)

18(2.2)

 

21(2.1)

18(2.5)

 

10(2.9)

29(2.1)

 
  1. Abbreviations: LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, PNI prognostic nutritional index