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Table 2 Associations of clinicopathological features with LMR, NLR, PLR and PNI in colorectal cancer

From: The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer

Variable LMR NLR PLR PNI
<  5.8 ≥  5.8 P <  2.0 ≥  2.0 P <  134.6 ≥  134.6 P <  46.4 ≥  46.4 P
Age(y)    0.086    0.001    0.556    < 0.001
 ≥ 60 700(58.7) 300(54.3)   499(53.7) 501(61.5)   588(57.9) 421(56.5)   233(68.1) 767(54.7)  
 < 60 492(41.3) 252(45.7)   431(46.3) 313(38.5)   427(42.1) 317(43.5)   109(31.9) 635(45.3)  
Gender    < 0.001    < 0.001    < 0.001    0.543
 Male 738(61.9) 244(44.2)   481(51.7) 501(61.5)   404(39.8) 371(50.9)   198(57.9) 784(55.9)  
 Female 454(38.1) 308(55.8)   449(48.3) 313(38.5)   611(60.2) 358(49.1)   144(42.1) 618(44.1)  
Tumor size (cm)    < 0.001    < 0.001    < 0.001    < 0.001
 ≥ 4.6 637(53.4) 238(43.1)   395(42.5) 480(59.0)   438(43.2) 437(59.9)   236(69.0) 639(45.6)  
 < 4.6 555(46.6) 314(56.9)   535(57.5) 334(41.0)   577(56.8) 292(40.1)   106(31.0) 763(54.4)  
Tumor location    < 0.001    0.073    < 0.001    < 0.001
 Colon 544(45.6) 196(35.5)   376(40.4) 364(44.7)   342(33.7) 398(54.6)   193(56.4) 547(39.0)  
 Rectum 648(54.4) 356(64.5)   554(59.6) 450(55.3)   673(66.3) 331(45.4)   149(43.6) 855(61.0)  
Differentiation    0.069    0.001    0.001    0.001
 Well - moderate 1086(91.1) 517(93.7)   873(93.9) 730(89.7)   952(93.8) 63(6.2)   299(87.4) 1304(93.0)  
 Poor - undifferentiated 106(8.9) 35(6.3)   57(6.1) 84(10.3)   651(89.3) 78(10.7)   43(12.6) 98(7.0)  
pT category    0.006    0.019    0.003    < 0.001
 T1 30(2.5) 22(4.0)   30(3.2) 22(2.7)   34(3.3) 18(2.5)   3(0.9) 49(3.5)  
 T2 188(15.8) 119(21.6)   187(20.1) 120(14.7)   206(20.3) 101(13.9)   39(11.4) 268(19.1)  
 T3 470(39.4) 197(35.7)   350(37.6) 317(38.9)   378(37.2) 289(39.6)   157(45.9) 510(36.4)  
 T4 504(42.3) 214(38.8)   363(39.0) 355(43.6)   397(39.1) 321(44.0)   143(41.8) 575(41.0)  
pN category    0.497    0.558    0.184    0.412
 pN0 689(57.8) 335(60.7)   557(59.9) 467(57.4)   611(60.2) 413(56.7)   194(56.7) 830(59.2)  
 pN1 365(30.6) 160(29.0)   273(29.4) 252(31.0)   301(29.7) 224(30.7)   103(30.1) 422(30.1)  
 pN2 138(11.6) 57(10.3)   100(10.8) 95(11.7)   103(10.1) 92(12.6)   45(13.2) 150(10.7)  
Distant metastasis    0.130    0.947    0.577    0.337
 Negative 1161(97.4) 544(98.6)   909(97.7) 796(97.8)   994(97.9) 711(97.5)   332(97.1) 1373(97.9)  
 Positive 31(2.6) 8(1.4)   21(2.3) 18(2.2)   21(2.1) 18(2.5)   10(2.9) 29(2.1)  
TNM stage    0.018    0.026    0.010    0.001
 I 176(14.8) 112(20.3)   177(19.0) 111(13.6)   193(19.0) 95(13.0)   32(9.4) 256(18.3)  
 II 505(42.4) 221(40.0)   376(40.4) 350(43.0)   415(40.9) 311(42.7)   158(46.2) 568(40.5)  
 III 480(40.3) 211(38.2)   356(38.3) 335(41.2)   386(38.0) 305(41.8)   142(41.5) 549(39.2)  
 IV 31(2.6) 8(1.4)   21(2.3) 18(2.2)   21(2.1) 18(2.5)   10(2.9) 29(2.1)  
  1. Abbreviations: LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, PNI prognostic nutritional index