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Table 5 Predicted targets for microRNAs differently deregulated in canine mammary cancer from human breast cancer

From: MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours

microRNA Metastatic canine mammary cancer Target gene Metastatic canine mammary cancer Gene’s name Gene’s function
cfa-miR-29a down-regulated PARD3B up-regulated Par-3 family cell polarity regulator beta cell cycle regulation
cfa-miR-181a down-regulated RAD21 up-regulated RAD21 homolog (S. pombe) cell cycle regulation, DNA-damage repair, cell differentiation
BCLAF1 up-regulated BCL2-associated transcription factor 1 cell differentiation
PRKAA1 up-regulated protein kinase, AMP-activated, alpha 1 catalytic subunit cell differentiation
YWHAG up-regulated tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide cell differentiation
ESCO2 up-regulated establishment of sister chromatid cohesion N-acetyltransferase 2 cell cycle regulation, DNA-damage repair
LBR up-regulated lamin B receptor receptor, cell adhesion
cfa-miR-374a down-regulated SPIN1 up-regulated spindlin 1 cell cycle regulation
BUB3 up-regulated BUB3 mitotic checkpoint protein cell cycle regulation, cell cycle checkpoint
RAD21 up-regulated RAD21 homolog (S. pombe) cell differentiation, cell cycle regulation, DNA-damage repair
SKIN up-regulated SKI-like oncogene cell differentiation