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Table 4 Cox regression multivariate analyses of factors associated with early mortality and early recurrence in hepatocellular carcinoma after hepatectomy

From: RAM score is an effective predictor for early mortality and recurrence after hepatectomy for hepatocellular carcinoma

  Multivariate analysis
  Hazard ratio (95% CI)j P -value
Early Mortality
 RAM scorea
  class II/III vs. class I 2.847 (1.884~4.302) <0.001
 ALBI scoreb   <0.001
  grade 2 vs. grade 1 2.309 (1.577~3.383) <0.001
  grade 3 vs. grade 1 N/Ak 0.953
 MELD scorec   0.271
  grade 2 vs. grade 1 1.218 (0.782~1.897) 0.384
  grade 3 vs. grade 1 1.873 (0.830~4.231) 0.131
 Alcohol consumption (Yes) 1.799 (1.105~2.930) 0.018
 Cigarette smoking (Yes) 1.110 (0.710~1.734) 0.648
 Age > 80 (year-old) 1.988 (0.907~4.354) 0.086
 Pre-OP symptomsd (Yes) 1.411 (0.956~2.083) 0.083
 Pre-OP treatmente (Yes) 1.271 (0.765~2.111) 0.355
 Pre-OP platelets < 100 (1000/uL) 1.453 (0.905~2.332) 0.122
 Pre-OP total bilirubin > 2.0 (mg/dL) 1.377 (0.469~4.039) 0.561
 Pre-OP hemoglobin < 10 (g/dL) 1.102 (0.596~2.038) 0.756
 ICG-15f > 10 (%) 1.081 (0.740~1.580) 0.687
 OP durationg > 270 (mins) 1.295 (0.875~1.915) 0.196
 Tumor size > 10 (cm) 1.770 (1.130~2.771) 0.013
Early Recurrence
 RAM scorea
  class II/III vs. class I 1.640 (1.352~1.988) <0.001
 ALBI scoreb   0.001
  grade 2 vs. grade 1 1.382 (1.190~1.606) <0.001
  grade 3 vs. grade 1 0.962 (0.301~3.077) 0.948
 MELD scorec   0.868
  grade 2 vs. grade 1 0.952 (0.787~1.150) 0.608
  grade 3 vs. grade 1 1.015 (0.683~1.509) 0.941
 Alcohol consumption (Yes) 1.249 (1.003~1.557) 0.047
 Cigarette smoking (Yes) 1.258 (1.057~1.498) 0.010
 Pre-OP symptomsd (Yes) 1.006 (0.855~1.184) 0.943
 Pre-OP treatmente (Yes) 1.183 (0.953~1.469) 0.127
 Pre-OP total bilirubin > 2.0 (mg/dL) 1.513 (0.921~2.487) 0.102
 Pre-OP hemoglobin < 10 (g/dL) 1.215 (0.903~1.634) 0.199
 Pre-OP ALTh > 40 (U/L) 1.077 (0.940~1.234) 0.284
 ICG-15f > 10% 1.347 (1.167~1.554) <0.001
 Tumor size > 10 (cm) 1.773 (1.456~2.160) <0.001
 Inflow controli (Yes) 1.162 (0.985~1.370) 0.075
  1. aRisk Assessment for early Mortality score
  2. balbumin–bilirubin score
  3. cModel for End-Stage Liver Disease score
  4. dpreoperative symptoms included anemia, jaundice, palpable mass and ascites
  5. epreoperative treatments included transarterial chemoembolization, percutaneous ethanol injection and radiofrequency ablation
  6. findocyanine green retention test at 15 min
  7. gduration of operation
  8. hpreoperative serum alanine aminotransferase level
  9. iinflow control included as Pringle’s maneuver, Glissonian pedicle control, selective vascular control and total vascular exclusion
  10. j95% confidence interval
  11. kNot Applicable