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Table 1 Summarized case reports of PCI associated with anti-angiogenic therapy

From: Pneumatosis cystoides intestinalis associated with sunitinib and a literature review

Case Number (Reference) Sex/Age Site Diagnostic tool Underlying disease Causative agent Associated symptoms Perforation Treatment Outcome Time to recovery
1 [14] M/54 Small intestine CT Pancreatic neuroendocrine tumor S1 plus bevacizumab Constipation No Observation Resolved 6 weeks
2 [16] F/Not described Colon CT, Biopsy Renal cell carcinoma Sunitinib Flank pain and anuria Yes Operation Resolved NA
3 [16] F/Not described Colon CT Renal cell carcinoma Sunitinib Diarrhea and abdominal pain Yes Observation Resolved 12 weeks
4 [17] M/73 Colon CT Gastrointestinal stromal tumor Sunitinib None Yes Observation Resolved 4 weeks
5 [18] F/40 Small intestine CT Fibrolamellar carcinoma Sorafenib Abdominal pain, fever Yes Observation Resolved 4 weeks
6 [18] F/48 Small intestine CT Papillary thyroid carcinoma Sunitinib Diarrhea and abdominal pain No Observation Resolved 4 weeks
7 [18] M/68 Small intestine CT Renal cell carcinoma Sunitinib None No Operation Resolved NA
8 [15] M/66 Small intestine CT Renal cell carcinoma Sunitinib Abdominal pain None Operation Resolved NA