Table 1 Summarized case reports of PCI associated with anti-angiogenic therapy
From: Pneumatosis cystoides intestinalis associated with sunitinib and a literature review
Case Number (Reference) | Sex/Age | Site | Diagnostic tool | Underlying disease | Causative agent | Associated symptoms | Perforation | Treatment | Outcome | Time to recovery |
|---|---|---|---|---|---|---|---|---|---|---|
1 [14] | M/54 | Small intestine | CT | Pancreatic neuroendocrine tumor | S1 plus bevacizumab | Constipation | No | Observation | Resolved | 6 weeks |
2 [16] | F/Not described | Colon | CT, Biopsy | Renal cell carcinoma | Sunitinib | Flank pain and anuria | Yes | Operation | Resolved | NA |
3 [16] | F/Not described | Colon | CT | Renal cell carcinoma | Sunitinib | Diarrhea and abdominal pain | Yes | Observation | Resolved | 12 weeks |
4 [17] | M/73 | Colon | CT | Gastrointestinal stromal tumor | Sunitinib | None | Yes | Observation | Resolved | 4 weeks |
5 [18] | F/40 | Small intestine | CT | Fibrolamellar carcinoma | Sorafenib | Abdominal pain, fever | Yes | Observation | Resolved | 4 weeks |
6 [18] | F/48 | Small intestine | CT | Papillary thyroid carcinoma | Sunitinib | Diarrhea and abdominal pain | No | Observation | Resolved | 4 weeks |
7 [18] | M/68 | Small intestine | CT | Renal cell carcinoma | Sunitinib | None | No | Operation | Resolved | NA |
8 [15] | M/66 | Small intestine | CT | Renal cell carcinoma | Sunitinib | Abdominal pain | None | Operation | Resolved | NA |