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Table 3 GRADE profile evidence of the included studies

From: Meta-analysis comparing laparoscopic versus open resection for gastric gastrointestinal stromal tumors larger than 5 cm

Outcome indicator No. of studies Quality assessment No. of patients Effect Quality Importance
Risk of bias Inconsistency Indirectness Imprecision publication bias LAP OPEN Relative (95% CI) Absolute   
Operation time 5 no serious risk of bias very seriousa no serious indirectness seriousb None 90 86   WMD −0.87
(−47.50~47.75)

very low
IMPORTANT
Blood loss 5 no serious risk of bias serious no serious indirectnessa seriousb None 89 108   WMD −34.38
(−79.60~10.84)

very low
IMPORTANT
Postoperative complications 6 no serious risk of bias no serious inconsistency no serious indirectness seriousa Maybed 185 194 RR 0.65
(0.38~1.12)c
 
low
CRITICAL
Postoperative hospital stay 6 no serious risk of bias very seriousa no serious indirectness seriousb None 113 122   WMD −2.01
(−3.83~ − 0.18)

very low
IMPORTANT
Overall recurrence rate 7 no serious risk of bias no serious inconsistency no serious indirectness seriousa None 203 214 RR 0.56
(0.29~1.06)c
 
moderate
CRITICAL
Disease-free survival 5 no serious risk of bias no serious inconsistency no serious indirectness no serious imprecision None 162 171 HR 0.40
(0.17~0.91)
 
moderate
CRITICAL
Overall survival 4 no serious risk of bias no serious inconsistency no serious indirectness serious None 149 158 HR 0.11
(0.03~0.43)
 
moderate
CRITICAL
  1. LAP laparoscopic resection, OPEN open resection
  2. ahave serious heterogeneity(I 2 > 75%)
  3. bthe sample size of included patients is too small
  4. cthe confidence interval of RR include 1
  5. dexist publication bias