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Table 2 Results of univariable and multivariable Cox regression models for overall survival

From: Cytoreductive surgery and Hyperthermic intra-operative peritoneal chemotherapy with Cisplatin for gastric peritoneal Carcinomatosis Monocentric phase-2 nonrandomized prospective clinical trial

 

N

Median OS

Univariable

Multivariable

Hazard ratio

p value

Hazard ratio

p value

Age (years)

    

0.260

  

Gender

    

0.712

  

BMI

    

0.122

  

ASA

2

15

12.2 (5.8-14.4)

 

0.037

0.170 (-0.299-0.638)

0.4730

3

17

18.2 (15.5-27.9)

Synchronous PC

    

0.999

  

Neo-adjuvant chemotherapy

No

2

8.6 (3-14.2)

 

0.054

0.443 (-0.562-1.281)

0.3459

Yes

30

17 (12.5-24.9)

Duration of surgery (minutes)

    

0.444

  

Intra-operative blood loss (ml)

    

0.619

  

Total PCI score

   

0.114 (0.018-0.212)

0.020

0.750 (0.180-1.344)

0.0104

Number of regions involved PC

   

0.167 (0.005-0.340)

0.042

1.290 (0.434-2.246)

0.0029

Small bowel PCI score

    

0.1511

  

Non-small bowel PCI score

    

0.068

0.564 (0.088-1.226)

0.0888

PC on small bowel

No

8

28.6 (14-36.6)

 

0.098

0.545 (0.195-1.268)

0.1453

Yes

24

14.3 (9.2-18.2)

Number of small bowel regions involved PC

    

0.497

  

Number of non-small bowel regions involved PC

    

0.078

0.910 (0.118-2.008)

0.0831

PC on any small bowel region with 4 or more non-small bowel regions

No

20

24.7 (15.6-29.4)

 

<0.0001

1.383 (0.624-2.177)

0.0004

Yes

12

10.5 (5.8-14.2)

Adjuvant chemotherapy

    

0.821

  

Postoperative complications

    

0.502

  
  1. 95% confidence intervals are mention between parentheses; OS times are mentioned in months
  2. ASA American society of anesthesiology, BMI body mass index, ml milliliters, N number, OS overall survival, PC peritoneal carcinomatosis, PCI peritoneal carcinomatosis index
  3. Independent predictors of OS were PC on the small bowel combined with PC on 4 or more non-small bowel regions (p = 0.0004), number of regions involved (p = 0.0029), and overall PCI score (p = 0.0104)