Fig. 5

Low ARS without elevated neuronal phenotype samples across clinical datasets. Twenty samples with low ARS and low/average neuronal phenotype scores were identified based on outlier-style cut-offs relative to adenocarcinomas (fold-change < -1, z-score < -2 for ARS; fold-change < 0.5, z-score < 1 for neuronal phenotype), including known unusual cases such as the case report adenocarcinoma 57634 (JHU-FFPE), and also samples from pure adenocarcinoma datasets (MSKCC). Differential expression analysis was notable for down-expression of RAB3B in this group relative to the remaining adenocarcinomas or NEPCs (Additional file 3: Figure S4). These samples also demonstrated a wide range of CCP scores (color axis), where low CCP possibly reflected response to treatment (Additional file 3: Figure S5)