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Fig. 4 | BMC Cancer

Fig. 4

From: Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma

Fig. 4

Hierarchical clustering of JHU-FFPE relative to meta-9 genes. There were 3 main groups, which we labeled “prototypical” adenocarcinomas, “prototypical” SCPCs, and “atypical” SCPCs, and which generally corresponded to pure adenocarcinomas, SCPCs with reduced ARS, and SCPCs with retained ARS respectively. The only exceptions were one SCPC outlier with retained ARS (57914) that clustered with prototypical adenocarcinomas, one pure adenocarcinoma outlier (57634) described previously in a case report that clustered with prototypical SCPCs, and heterogeneous behavior of mixed adenocarcinomas. The adenocarcinoma 57634 clustered near 56322, an SCPC with negative IHC for all 3 neuroendocrine markers synaptophysin, chromogranin, and CD56. The oldest SCPC’s (54674 and 56321_S) had low CCP and also clustered together. Meta-9 clustering was consistent with subsequent nearest centroid classification based on 9 prototypical SCPC, 9 prototypical adenocarcinoma, and 4 atypical SCPC with LIMMA-based feature selection (Fig. 6)

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