Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma

Fig. 3

Hybrid immunohistochemistry of an unusual mixed tumor. A hybrid IHC profile was observed in an unusual mixed case from JHU-FFPE with concurrent small cell (57912_S) and Gleason 5+4 adenocarcinoma (57912_A) components. The SCPC component appeared to uniformly co-express androgen-related markers (Nkx3.1, AR) and neuroendocrine markers (synaptophysin and CD56/NCAM1 but not chromogranin) by IHC. Unusually, IHC was negative for PSA despite moderate expression of the underlying gene KLK3 (Additional file 3: Figure S11). By contrast, the adenocarcinoma component was IHC positive for PSA and negative for synaptophysin and CD56. Both components were IHC negative for cyclin D1, a proposed marker of SCPC [21]

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us