Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study

Table 3 Associations with the occurrence of CRC (univariate, multivariate conditional logistic regression and after 1000 bootstrapped multivariate conditional logistic regressions) for clinical covariates

Covariates	Model	Univariate^a			Multivariate^b			Bootstrapped multivariate analysis^b			% of bootstrap selection
Covariates	Model	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	% of bootstrap selection
Living	Rural / Mix vs. Urban	2.82	1.96–4.06	p < 0.0001	2.50	1.48–4.23	p = 0.0006	2.26	1.36–3.75	0.0015	87
Job	Rural / Mix vs. Urban	3.44	2.24–5.29	p < 0.0001	2.99	1.63–5.48	p = 0.0004	2.93	1.61–5.34	0.0004	87
Red meat consumption	≥3 portions/week vs. <3	1.63	1.01–2.63	p = 0.0458							45
Tobacco consumption	Tobacco exposure <30 years vs. never	0.86	0.60–1.25	p = 0.4290	1.17	0.70–1.95	0.5439	1.13	0.69–1.84	0.6235	73
Tobacco consumption	Tobacco exposure ≥30 years vs. never	1.82	1.10–3.03	p = 0.0207	3.37	1.63–6.96	0.0010	2.73	1.39–5.39	0.0036	73
Alcohol consumption	> 30 g/day now or in the past vs. ≤ 30 g/day	2.62	1.49–4.59	p = 0.0008	1.06	0.50–2.22	0.8725				26
	Never vs. ≤ 30 g/day	2.75	1.77–4.27	p < 0.0001	3.05	1.69–5.50	0.0002				26
Physical activity	<30 vs. ≥ 30 min/day	5.83	3.74–9.07	p < 0.0001	6.35	3.70–10.9	p < 0.0001	6.73	4.07–11.14	p < 0.0001	100

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