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Table 2 Cell lines and other materials, and characteristics of articles considered in this review

From: Alterations in PGC1α expression levels are involved in colorectal cancer risk: a qualitative systematic review

Title Main Material Characteristics
Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein HT-29 (Cell line) i) Human.
ii) Epithelial
SNU-C4 (Cell line) i) Human
CT-26 (Cell line) i) Mouse.
ii) Epithelial
PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine iPGC1b mouse model with human PGC1b i) Transgenic mouse
iPGC1b knockout mice
iPGC1b Apc Min/+ Mice
Mitochondria and Tumor Progression in Ulcerative Colitis Ulcerative Colitis progressor (Human) i) Human
Ulcerative Colitis non progressor (Human)
PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis. PGC1a knockout mice i) Transgenic mouse
PGC1a +/+ mice
SCID mice (HT29) i) Inoculated mouse
HT29 (Cell line) i) Human.
ii) Epithelial
Colo205 (Cell line) i) Human.
ii) Epithelial
Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells HCT116 (Cell line)
Nude mice (subcutaneously injected both cells)
i) Human
ii) Epithelial
i) Inoculated mouse
PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations VACO425 (Cell line) i) Human
VACO429 (Cell line) i) Human
Validation of the Use of DNA Pools and Primer Extension in Association Studies of Sporadic Colorectal Cancer for Selection of Candidate SNPs Two pools of genomic DNA (patients with sporadic CRC + controls) i) Human
SIRT1/PGC1a-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer Colonosphere cultures shSIRT1 (Human colorectal tumor specimens) i) Human colonosphere cultures
Colonosphere cultures shPGC1a (Human colorectal tumor specimens)
AMPK Promotes Aberrant PGC1b Expression To Support Human Colon Tumor Cell Survival HCT116 (Cell line) i) Human.
ii) Epithelial
Inmunodeficient mice (HCT116 cells grafted into mice) i) Inoculated mouse
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate HT29 (Cell line) i) Human.
ii) Epithelial
HCT116 (Cell line) i) Human.
ii) Epithelial
HT29p0 (Cell line: Completely lacks mitochondrial DNA) i) Human.
ii) Epithelial
Xenograft mice using HT29 cells i) Inoculated mouse
iPGC1a transgenic mice i) Transgenic mouse
PGC1a +/+ mice and PGC1−/− mice
Peroxisome Proliferator-Activated Receptor gamma Coactivator-1 Enhances Antiproliferative Activity of 5 -Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase Colo320 (Cell line) i) Human.
ii) Undifferentiated
HCT116 (Cell line) i) Human.
ii) Epithelial
Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARg-coactivator 1 (PGC-1) Colorectal cancers from patients (Human) i) Human