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Table 2 Genotype and allele frequencies of ADH1A, ADH1B, ADH1C and ALDH2 gene and association with gastric cancer risk

From: Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India

Genotype Controls(n-108)
n (%)
Cases (n-105)
n (%)
ORa (95% CI) p-value
ADH1A
rs1230025
 TT 52 (48.1) 45 (42.9) 1.00  
 TA 46 (42.6) 57 (54.3) 1.10 (0.55–2.19)  
 AA 10 (9.3) 3 (2.9) 0.28 (0.05–1.55) 0.284
 TT 52 (48.1) 45 (42.9) 1.00  
 TA + AA 56 (51.9) 60 (57.1) 0.96 (0.49–1.87) 0.893
 TT + TA 98 (90.7) 102 (97.1) 1.00  
 AA 10 (9.3) 3 (2.9) 0.27 (0.05–1.44) 0.099
 T allele 69% 70% 1.00  
 A allele 31% 30% 0.95 (0.63–1.44) 0.819
ADH1B
rs3811802
 TT 62 (57.4) 54 (51.4) 1.00  
 TC 44 (40.7) 51 (48.6) 1.37 (0.79–2.38) 0.162
 CC 2 (1.9) 0 (0.0)  
 TT 62 (57.4) 54 (51.4) 1.00  
 CT + TT 46 (42.6) 51 (48.6) 1.32 (0.76–2.29) 0.316
 T allele 78% 76% 1.00  
 C allele 22% 24% 1.09 (0.70–1.72) 0.697
ADH1B
rs1229982
 CC 78 (72.2) 74 (70.5) 1.00  
 CA 28 (25.9) 30 (28.6) 0.92 (0.42–2.01)  
 AA 2 (1.9) 1 (1.0) 0.89 (0.06–13.66) 0.974
 CC 78 (72.2) 74 (70.5) 1.00  
 CA + AA 30 (27.8) 31 (29.5) 0.91 (0.42–1.99) 0.820
 CC + CA 106 (98.1) 104 (99.0) 1.00  
 AA 2 (1.9) 1 (1.0) 0.93 (0.06–13.87) 0.957
 C allele 85% 85% 1.00  
 A allele 15% 15% 1.00 (0.59–1.69) 0.991
ADH1B
rs1229984
 GG 107 (99.1) 104 (99.0) 1.00  
 GA 1 (0.9) 1 (1.0) 1.44 (0.02–130.3) 0.874
 G allele 100% 100% 1.00  
 A allele 0% 0%
ADH1B
rs4147536
 GG 56 (51.9) 62 (59.0) 1.00  
 GT 41 (38.0) 41 (39.0) 1.03 (0.53–2.00)  
 TT 11 (10.2) 2 (1.9) 0.22 (0.04–1.12) 0.114
 GG 56 (51.9) 62 (59.0) 1.00  
 GT + TT 52 (48.1) 43 (41.0) 0.86 (0.46–1.62) 0.636
 GG + GT 97 (89.8) 103 (98.1) 1.00  
 TT 11 (10.2) 2 (1.9) 0.18 (0.04–0.82) 0.009
 G allele 71% 79% 1.00  
 T allele 29% 21% 0.66 (0.43–1.03) 0.066
ADH1B
rs17033
 AA 101 (93.5) 85 (81.0) 1.00  
 AG 7 (6.5) 17 (16.2) 2.38 (0.84–6.75) 0.054
 GG 0 (0.0) 3 (2.9)  
 AA 101 (93.5) 85 (81.0) 1.00  
 AG + GG 7 (6.5) 20 (19.0) 2.80 (1.02–7.70) 0.039
 A allele 97% 89% 1.00  
 G allele 3% 11% 3.67 (1.54–8.75) 0.002
ADH1C
rs698
 AA 60 (55.6) 61 (58.1) 1.00  
 AG 41 (38.0) 34 (32.4) 0.62 (0.30–1.29)  
 GG 7 (6.5) 10 (9.5) 2.04 (0.53–7.89) 0.189
 AA 60 (55.6) 61 (58.1) 1.00  
 AG + GG 48 (44.4) 44 (41.9) 0.76 (0.39–1.51) 0.435
 AA + AG 101 (93.5) 95 (90.5) 1.00  
 GG 7 (6.5) 10 (9.5) 2.40 (0.63–9.10) 0.196
 A allele 75% 74% 1.00  
 G allele 25% 26% 1.06 (0.69–1.65) 0.778
ALDH2
rs886205
 AA 35 (32.4) 35 (33.3) 1.00  
 AG 56 (51.9) 45 (42.9) 0.75 (0.34–1.63)  
 GG 17 (15.7) 25 (23.8) 1.58 (0.59–4.21) 0.255
 AA 35 (32.4) 35 (33.3) 1.00  
 AG + GG 73 (67.6) 70 (66.7) 0.92 (0.44–1.93) 0.832
 AA + AG 91 (84.3) 80 (76.2) 1.00  
 GG 17 (15.7) 25 (23.8) 1.89 (0.81–4.43) 0.137
 A allele 58% 55% 1.00  
 G allele 42% 45% 1.13 (0.77–1.66) 0.518
ALDH2
rs671
 GG 104 (96.3) 88 (83.8) 1.00  
 GA 4 (3.7) 15 (14.3) 5.04 (1.37–18.57) 0.021
 AA 0 (0.0) 2 (1.9)   
 GG 104 (96.3) 88 (83.8) 1.00  
 GA + AA 4 (3.7) 17 (16.2) 5.30 (1.46–19.20) 0.006
 G allele 98% 91% 1.00  
 A allele 2% 9% 4.20 (1.54–11.46) 0.003
ALDH2
rs968529
 CC 101 (93.5) 101 (96.2) 1.00  
 CT 7 (6.5) 4 (3.8) 0.36 (0.08–1.73) 0.371
 C allele 97% 98% 1.00  
 T allele 3% 2% 0.73 (0.23–2.33) 0.592
ALDH2
rs16941667
 CC 104 (96.3) 97 (92.4) 1.00  
 CT 3 (2.8) 7 (6.7) 3.49 (0.52–23.24) 0.294
 TT 1 (0.9) 1 (1.0) 0.19 (0.00–11.13)  
 CC 104 (96.3) 97 (92.4) 1.00  
 CT + TT 4 (3.7) 8 (7.6) 2.03 (0.39–10.60) 0.395
 CC + CT 107 (99.1) 104 (99.0) 1.00  
 TT 1 (0.9) 1 (1.0) 0.19 (0.00–10.94) 0.408
 C allele 98% 96% 1.00  
 T allele 2% 4% 1.89 (0.62–5.73) 0.254
  1. aOdds ratio were adjusted for age, sex, BMI, alcohol and smoking status, p value < 0.05 is considered to be statistically significant