Table 2 Genotype and allele frequencies of ADH1A, ADH1B, ADH1C and ALDH2 gene and association with gastric cancer risk
Genotype | Controls(n-108) n (%) | Cases (n-105) n (%) | ORa (95% CI) | p-value |
|---|---|---|---|---|
ADH1A rs1230025 | ||||
 TT | 52 (48.1) | 45 (42.9) | 1.00 |  |
 TA | 46 (42.6) | 57 (54.3) | 1.10 (0.55–2.19) |  |
 AA | 10 (9.3) | 3 (2.9) | 0.28 (0.05–1.55) | 0.284 |
 TT | 52 (48.1) | 45 (42.9) | 1.00 |  |
 TA + AA | 56 (51.9) | 60 (57.1) | 0.96 (0.49–1.87) | 0.893 |
 TT + TA | 98 (90.7) | 102 (97.1) | 1.00 |  |
 AA | 10 (9.3) | 3 (2.9) | 0.27 (0.05–1.44) | 0.099 |
 T allele | 69% | 70% | 1.00 |  |
 A allele | 31% | 30% | 0.95 (0.63–1.44) | 0.819 |
ADH1B rs3811802 | ||||
 TT | 62 (57.4) | 54 (51.4) | 1.00 |  |
 TC | 44 (40.7) | 51 (48.6) | 1.37 (0.79–2.38) | 0.162 |
 CC | 2 (1.9) | 0 (0.0) | – |  |
 TT | 62 (57.4) | 54 (51.4) | 1.00 |  |
 CT + TT | 46 (42.6) | 51 (48.6) | 1.32 (0.76–2.29) | 0.316 |
 T allele | 78% | 76% | 1.00 |  |
 C allele | 22% | 24% | 1.09 (0.70–1.72) | 0.697 |
ADH1B rs1229982 | ||||
 CC | 78 (72.2) | 74 (70.5) | 1.00 |  |
 CA | 28 (25.9) | 30 (28.6) | 0.92 (0.42–2.01) |  |
 AA | 2 (1.9) | 1 (1.0) | 0.89 (0.06–13.66) | 0.974 |
 CC | 78 (72.2) | 74 (70.5) | 1.00 |  |
 CA + AA | 30 (27.8) | 31 (29.5) | 0.91 (0.42–1.99) | 0.820 |
 CC + CA | 106 (98.1) | 104 (99.0) | 1.00 |  |
 AA | 2 (1.9) | 1 (1.0) | 0.93 (0.06–13.87) | 0.957 |
 C allele | 85% | 85% | 1.00 |  |
 A allele | 15% | 15% | 1.00 (0.59–1.69) | 0.991 |
ADH1B rs1229984 | ||||
 GG | 107 (99.1) | 104 (99.0) | 1.00 |  |
 GA | 1 (0.9) | 1 (1.0) | 1.44 (0.02–130.3) | 0.874 |
 G allele | 100% | 100% | 1.00 |  |
 A allele | 0% | 0% | – | – |
ADH1B rs4147536 | ||||
 GG | 56 (51.9) | 62 (59.0) | 1.00 |  |
 GT | 41 (38.0) | 41 (39.0) | 1.03 (0.53–2.00) |  |
 TT | 11 (10.2) | 2 (1.9) | 0.22 (0.04–1.12) | 0.114 |
 GG | 56 (51.9) | 62 (59.0) | 1.00 |  |
 GT + TT | 52 (48.1) | 43 (41.0) | 0.86 (0.46–1.62) | 0.636 |
 GG + GT | 97 (89.8) | 103 (98.1) | 1.00 |  |
 TT | 11 (10.2) | 2 (1.9) | 0.18 (0.04–0.82) | 0.009 |
 G allele | 71% | 79% | 1.00 |  |
 T allele | 29% | 21% | 0.66 (0.43–1.03) | 0.066 |
ADH1B rs17033 | ||||
 AA | 101 (93.5) | 85 (81.0) | 1.00 |  |
 AG | 7 (6.5) | 17 (16.2) | 2.38 (0.84–6.75) | 0.054 |
 GG | 0 (0.0) | 3 (2.9) | – |  |
 AA | 101 (93.5) | 85 (81.0) | 1.00 |  |
 AG + GG | 7 (6.5) | 20 (19.0) | 2.80 (1.02–7.70) | 0.039 |
 A allele | 97% | 89% | 1.00 |  |
 G allele | 3% | 11% | 3.67 (1.54–8.75) | 0.002 |
ADH1C rs698 | ||||
 AA | 60 (55.6) | 61 (58.1) | 1.00 |  |
 AG | 41 (38.0) | 34 (32.4) | 0.62 (0.30–1.29) |  |
 GG | 7 (6.5) | 10 (9.5) | 2.04 (0.53–7.89) | 0.189 |
 AA | 60 (55.6) | 61 (58.1) | 1.00 |  |
 AG + GG | 48 (44.4) | 44 (41.9) | 0.76 (0.39–1.51) | 0.435 |
 AA + AG | 101 (93.5) | 95 (90.5) | 1.00 |  |
 GG | 7 (6.5) | 10 (9.5) | 2.40 (0.63–9.10) | 0.196 |
 A allele | 75% | 74% | 1.00 |  |
 G allele | 25% | 26% | 1.06 (0.69–1.65) | 0.778 |
ALDH2 rs886205 | ||||
 AA | 35 (32.4) | 35 (33.3) | 1.00 |  |
 AG | 56 (51.9) | 45 (42.9) | 0.75 (0.34–1.63) |  |
 GG | 17 (15.7) | 25 (23.8) | 1.58 (0.59–4.21) | 0.255 |
 AA | 35 (32.4) | 35 (33.3) | 1.00 |  |
 AG + GG | 73 (67.6) | 70 (66.7) | 0.92 (0.44–1.93) | 0.832 |
 AA + AG | 91 (84.3) | 80 (76.2) | 1.00 |  |
 GG | 17 (15.7) | 25 (23.8) | 1.89 (0.81–4.43) | 0.137 |
 A allele | 58% | 55% | 1.00 |  |
 G allele | 42% | 45% | 1.13 (0.77–1.66) | 0.518 |
ALDH2 rs671 | ||||
 GG | 104 (96.3) | 88 (83.8) | 1.00 |  |
 GA | 4 (3.7) | 15 (14.3) | 5.04 (1.37–18.57) | 0.021 |
 AA | 0 (0.0) | 2 (1.9) |  |  |
 GG | 104 (96.3) | 88 (83.8) | 1.00 |  |
 GA + AA | 4 (3.7) | 17 (16.2) | 5.30 (1.46–19.20) | 0.006 |
 G allele | 98% | 91% | 1.00 |  |
 A allele | 2% | 9% | 4.20 (1.54–11.46) | 0.003 |
ALDH2 rs968529 | ||||
 CC | 101 (93.5) | 101 (96.2) | 1.00 |  |
 CT | 7 (6.5) | 4 (3.8) | 0.36 (0.08–1.73) | 0.371 |
 C allele | 97% | 98% | 1.00 |  |
 T allele | 3% | 2% | 0.73 (0.23–2.33) | 0.592 |
ALDH2 rs16941667 | ||||
 CC | 104 (96.3) | 97 (92.4) | 1.00 |  |
 CT | 3 (2.8) | 7 (6.7) | 3.49 (0.52–23.24) | 0.294 |
 TT | 1 (0.9) | 1 (1.0) | 0.19 (0.00–11.13) |  |
 CC | 104 (96.3) | 97 (92.4) | 1.00 |  |
 CT + TT | 4 (3.7) | 8 (7.6) | 2.03 (0.39–10.60) | 0.395 |
 CC + CT | 107 (99.1) | 104 (99.0) | 1.00 |  |
 TT | 1 (0.9) | 1 (1.0) | 0.19 (0.00–10.94) | 0.408 |
 C allele | 98% | 96% | 1.00 |  |
 T allele | 2% | 4% | 1.89 (0.62–5.73) | 0.254 |