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Fig. 4 | BMC Cancer

Fig. 4

From: Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma

Fig. 4

Differentially expressed miRNAs in eBL compared to GC B cells. a. Heatmap of differentially expressed (DE) miRNAs between eBL tumor cells and GC (Germinal center) B cells. The heatmap shows the hierarchical clustering based on the expression profiles of the 49 DE miRNAs with at least 2-fold difference in expression compared to their normal counterpart. b. Volcano plot representing the significance miRNAs (−log of the adjusted p-value) vs the fold change difference in eBL compared to GC B-cells. The red and blue colored circles represent miRNAs which are DE with p < 0.01 and FDR < 0.01. The 27 down-regulated miRNAs in eBL are colored blue (have a negative fold-change value) while the 22 up-regulated miRNAs in eBL are colored red (positive fold-change value)

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