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Fig. 1 | BMC Cancer

Fig. 1

From: Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform

Fig. 1

Microtiter cancer-on-a-chip plate for 3D breast cancer therapy response testing. a Photo of OrganoPlate® platform consisting of 96 perfusable microfluidic chambers in parallel. b Closeup, (c) top and (d) side view of an individual chamber consisting of an ECM channel and a Medium channel. Cells are premixed into a gel solution, loaded into the ECM channel by capillary action and allowed to polymerize before the introduction of medium into the adjacent Medium channel for culture. PhaseGuide™ allows the gel solution to be pinned during the loading and polymerization step, thereby allowing support-free and unhindered exchange with the medium. e Photo demonstrates the filling of the ECM channel using a red dye

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