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A novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D–culture methods for hepatocellular carcinoma

  • Jun Hou1,
  • Zhixian Hong2,
  • Fan Feng1,
  • Yantao Chai1,
  • Yunkai Zhang1,
  • Qiyu Jiang1,
  • Yan Hu1,
  • Shunquan Wu1,
  • Yingsong Wu3,
  • Xunian Gao4,
  • Qiong Chen3,
  • Yong Wan3,
  • Jingfeng Bi1Email author and
  • Zheng Zhang1Email author
Contributed equally
BMC Cancer201717:729

https://doi.org/10.1186/s12885-017-3706-6

Received: 8 November 2016

Accepted: 26 October 2017

Published: 8 November 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
8 Nov 2016 Submitted Original manuscript
4 Dec 2016 Author responded Author comments - Zheng Zhang
Resubmission - Version 2
4 Dec 2016 Submitted Manuscript version 2
19 Feb 2017 Reviewed Reviewer Report - Masoud Darabi
24 Feb 2017 Reviewed Reviewer Report - Lory Croce' Saveria
7 Jul 2017 Author responded Author comments - Zheng Zhang
Resubmission - Version 3
7 Jul 2017 Submitted Manuscript version 3
11 Jul 2017 Reviewed Reviewer Report - Masoud Darabi
16 Jul 2017 Reviewed Reviewer Report - Lory Croce' Saveria
14 Aug 2017 Author responded Author comments - Zheng Zhang
Resubmission - Version 4
14 Aug 2017 Submitted Manuscript version 4
12 Sep 2017 Author responded Author comments - Zheng Zhang
Resubmission - Version 5
12 Sep 2017 Submitted Manuscript version 5
30 Sep 2017 Author responded Author comments - Jun Hou
Resubmission - Version 6
30 Sep 2017 Submitted Manuscript version 6
Publishing
26 Oct 2017 Editorially accepted
8 Nov 2017 Article published 10.1186/s12885-017-3706-6

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Research Center for Clinical and Translational Medicine, the 302nd Hospital of Chinese PLA
(2)
Department of Hepatobiliary Surgery, the 302nd Hospital of Chinese PLA
(3)
School of Laboratory Medicine and Biotechnology, Southern Medical University
(4)
Research Institute, Guangzhou Darui Biotechnology Co Ltd

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