Table 3 Results of subgroup analyses on OS
Variables | HR[95%CI] | Number | I2 | Pd |
|---|---|---|---|---|
Year > mediana | ||||
 Yes | 3.65[2.49–5.36] | 6 | 0.00% | 0.578 |
 No | 2.44[1.19–4.99] | 7 | 72.90% | 0.001 |
Country | ||||
 East Asia | 3.39[2.27–5.05] | 10 | 46.50% | 0.051 |
 Non-East Asia | 2.10[0.52–8.54] | 3 | 74.50% | 0.02 |
Marker | ||||
 Single | 2.72[1.48–5.00] | 9 | 66.80% | 0.002 |
 Multiple | 3.77[2.62–5.43] | 4 | 0.00% | 0.799 |
Sampling time point | ||||
 Pre-op | 3.65[2.49–5.36] | 6 | 0.00% | 0.578 |
 Intra/post-op | 2.44[1.19–4.99] | 7 | 72.90% | 0.001 |
Patient no. > medianb | ||||
 Yes | 3.45[2.57–4.65] | 6 | 0.00% | 0.801 |
 No | 2.59[1.08–6.22] | 7 | 74.20% | 0.001 |
Detection rate > meanc | ||||
 Yes | 1.57[0.42–5.79] | 4 | 74.10% | 0.009 |
 No | 3.71[2.84–4.85] | 9 | 0.00% | 0.796 |
Quality of study | ||||
 Low | 4.06[1.64–10.05] | 2 | 0.00% | 0.384 |
 High | 2.95[1.87–4.65] | 11 | 61.50% | 0.004 |
Overall | 3.07[2.05–4.62] | 13 | 55.70% | 0.008 |