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Table 2 The assessment of the risk of bias in each Cohort study using the Newcastle-Ottawa Scale

From: Prognostic and clinicopathological significance of circulating tumor cells detected by RT-PCR in non-metastatic colorectal cancer: a meta-analysis and systematic review

Study

Selection (0–4)

Comparability (0–2)

Outcome (0–3)

Total

REC

SNEC

AE

DO

SC

AF

AO

FU

AFU

 

Kust 2016 [20]

0

1

1

1

0

0

0

1

0

4

Liu 2013 [28]

0

1

1

1

0

0

1

1

0

5

Yokobori 2013 [29]

1

1

1

1

0

0

1

1

0

6

Shimada 2012 [19]

1

1

1

1

0

0

1

1

1

7

Iimuna 2011 [30]

0

1

1

1

0

0

1

1

0

5

Uen 2008 [31]

0

1

1

1

0

0

1

1

0

5

Barreto 2007 [32]

0

0

1

1

0

0

1

1

0

4

Koch 2006 [33]

0

1

1

1

0

0

1

0

0

4

Lloyd 2006 [34]

0

0

1

1

0

0

1

0

0

3

Sadahrio 2005 [35]

1

1

1

1

0

0

1

1

1

7

Bessa 2003 [36]

0

1

1

1

0

0

1

1

0

5

Ito 2002 [37]

0

1

1

1

0

0

1

1

0

5

  1. NOTE: REC representativeness of the exposed cohort, SNEC selection of the non-exposed cohort, AE ascertainment of exposure; DO: demonstration that outcome of interest was not present at start of study, SC study controls for age, sex, AF study controls for any additional factors (chemoradiotherapy, curative resection), AO assessment of outcome, FU follow-up long enough (36 M) for outcomes to occur, AFU adequacy of follow-up of cohorts (≥90%).Total: the points of each study