Fig. 2

Multivariable-adjusted hazard ratios of all-cause mortality according to total postdiagnostic physical activity in CRC survivors (n = 1376), calculated with restricted cubic spline regression. The solid line depicts hazard ratios and the dashed lines are the 95% CIs. The points indicate the knots on 5th, 35th, 65th, and 95th percentiles. The reference value is the median (44 MET-hours/week) of the first quartile of total physical activity. The model was adjusted for sex, age at physical activity assessment, BMI, survival time from CRC diagnosis until physical activity assessment, tumor location, occurrence of metastases, occurrence of other cancer, chemotherapy, smoking status, and alcohol intake. The p value for nonlinearity is 0.01 (Wald chi-square test). Abbreviations: BMI, body mass index; CRC, colorectal cancer; MET, metabolic equivalent of task