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Table 3 IC50 values (μM) from MTT assays and corresponding shift factors (SF) of cisplatin alone and after 48 h pretreatment with 1.5 μM NVP-AEW541, 2 μM lapatinib, 20 nM NVP-BEZ235, or 1.5 μM NVP-AEW541 plus 2 μM lapatinib, respectively, in MDA-MB231 and MDA-MB231CisR cells

From: Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38

Compound MDA-MB231 MDA-MB231 CisR
IC50 SF IC50 SF
cisplatin 20.9 --- 44.0 ---
cisplatin + AEW541 22.8 0.9 23.3 1.9
cisplatin + lapatinib 24.1 0.9 24.7 1.8
cisplatin + BEZ235 22.8 0.9 21.8 2.0*
cisplatin + AEW541 + lapatinib 10.1 2.1* 9.16 4.8*
  1. * p < 0.05
  2. Data are mean of 3 experiments