Table 3 IC50 values (μM) from MTT assays and corresponding shift factors (SF) of cisplatin alone and after 48 h pretreatment with 1.5 μM NVP-AEW541, 2 μM lapatinib, 20 nM NVP-BEZ235, or 1.5 μM NVP-AEW541 plus 2 μM lapatinib, respectively, in MDA-MB231 and MDA-MB231CisR cells
Compound | MDA-MB231 | MDA-MB231 CisR | ||
|---|---|---|---|---|
IC50 | SF | IC50 | SF | |
cisplatin | 20.9 | --- | 44.0 | --- |
cisplatin + AEW541 | 22.8 | 0.9 | 23.3 | 1.9 |
cisplatin + lapatinib | 24.1 | 0.9 | 24.7 | 1.8 |
cisplatin + BEZ235 | 22.8 | 0.9 | 21.8 | 2.0* |
cisplatin + AEW541Â +Â lapatinib | 10.1 | 2.1* | 9.16 | 4.8* |